ArticleThe Journal of urology2014
Effect of aging on storage and voiding function in women with stress predominant urinary incontinence.
Article in The Journal of urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Normative noninvasive bladder function measurements in healthy women: A systematic review and meta-analysis.Neurourology and urodynamics · 2020Pooled it
- A Novel Technology for Needle-Free Injections of Liquids, Particles and Viable Cells into the Submucosa of the Urethra by a Pressure-Controlled Waterjet Technology.Biomedicines · 2025Article
- The Role of Anterior Vaginal Prolapse in Co-Existent Underactive Overactive Bladder Syndrome-A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Urinary retention is rare after colpocleisis and concomitant midurethral sling: a 10-year experience.International urogynecology journal · 2021Article
- Change of Detrusor Contractility in Patients with and without Bladder Outlet Obstruction at Ten or More Years of follow-up.Scientific reports · 2019Article
- Can we define and characterize the aging lower urinary tract?-ICI-RS 2015.Neurourology and urodynamics · 2017Review
- Outcomes of Surgery for Stress Urinary Incontinence in the Older Woman.Clinics in geriatric medicine · 2015Review
- Effect of aging on urodynamic parameters in women with stress urinary incontinence.Korean journal of urology · 2015Article
- Pathophysiology and animal modeling of underactive bladder.International urology and nephrology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe investigated age related changes in urodynamic parameters in 2 large cohorts of women planning stress urinary incontinence surgery. MATERIALS AND
methodsUsing a standardized protocol we obtained urodynamic parameters for participants in SISTEr (Stress Incontinence Surgical Treatment Efficacy Trial) and TOMUS (Trial of Mid-Urethral Slings) undergoing baseline noninvasive flow followed by filling cystometrogram and pressure flow study. The bladder contractility index (defined as detrusor pressure at maximum flow+5×maximum flow) and detrusor hypocontractility (defined as detrusor pressure at maximum flow less than 10 cm H2O) were also characterized. Patients excluded from analysis had undergone prior stress urinary incontinence surgery or had prolapse stage greater than II. Propensity score analysis controlled for the potential bias of combining participants from 2 clinical trials. Linear and logistic regression analysis adjusting for propensity score quintile was done to assess the association of age and an age cutoff (less than 65 vs 65 or greater years) with urodynamic parameters.
resultsA total of 945 women (468 in SISTEr and 477 in TOMUS) were included in analysis. Mean age was 50 years in SISTEr (range 27 to 75) and 51 years (range 24 to 82) in TOMUS. Noninvasive maximum urinary flow decreased significantly with age (26.2 vs 22 ml per second, p=0.002). Noninvasive flow voiding time increased 2.7 seconds for each 10-year age increment and detrusor pressure at maximum flow decreased 2.1 cm H2O for each 10-year increase in age (each p=0.003). Hypocontractility was more likely in women 65 years old or older (OR 2.89, 95% CI 1.59, 5.27). The bladder contractility index was inversely related to age, decreasing a mean±SD of 7.68±1.96 cm H2O for each 10-year age increase (p<0.001).
conclusionsIn these 2 cohorts the observed changes in voiding parameters suggest that detrusor contractility and efficiency decrease with age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.