Evidence map›Paper›PMID 24518754›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2015

Diffusion MR Microscopy of Cortical Development in the Mouse Embryo.

Manisha Aggarwal, Ilan Gobius, Linda J Richards, Susumu Mori

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A diffusion MRI-based spatiotemporal continuum of the embryonic mouse brain for probing gene-neuroanatomy connections.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Article
  9. Using diffusion anisotropy to study cerebral cortical gray matter development.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018
    Review
  10. Folding, But Not Surface Area Expansion, Is Associated with Cellular Morphological Maturation in the Fetal Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Manisha AggarwalRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ilan GobiusQueensland Brain Institute.
Linda J RichardsQueensland Brain Institute School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Susumu MoriRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Allen Institute for Brain Science · USJohns Hopkins University · USKennedy Krieger Institute · USUniversity of Queensland · AU

Funding

Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
MR Microimaging of Mouse Brain DevelopmentR01EB003543 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MORI, SUSUMU · 2004 to 2012
$4.5M
Human White Matter Tract Mapping by Diffusion MRIR01AG020012 · NIA · JOHNS HOPKINS UNIVERSITY · PI MORI, SUSUMU · 2001 to 2011
$4.1M
NIA NIH HHS R01AG020012NIBIB NIH HHS R01EB003543NICHD NIH HHS U54 HD079123
6 · The paper itself

Abstract

Cortical development in the mouse embryo involves complex changes in the microstructure of the telencephalic wall, which are challenging to examine using three-dimensional (3D) imaging techniques. In this study, high-resolution 3D diffusion magnetic resonance (dMR) microscopy of the embryonic mouse cortex is presented. Using diffusion-weighted gradient- and spin-echo based acquisition, dMR microimaging data were acquired from fixed mouse embryos at 7 developmental stages from embryonic day (E)12.5 to E18.5. The dMR imaging (dMRI) contrasts revealed microscopic structural detail in the mouse telencephalic wall, allowing delineation of transient zones in the developing cortex based on their unique diffusion signatures. With the high-resolution 3D data of the mouse embryo, we were able to visualize the complex microstructure of embryonic cerebral tissue and to resolve its regional and temporal evolution during cortical formation. Furthermore, averaged dMRI contrasts generated via deformable registration revealed distinct spatial and temporal gradients of anisotropy variation across the developing embryonic cortical plate and the ventricular zone. The findings of this study demonstrate the potential of 3D dMRI to resolve the complex microstructure of the embryonic mouse cortex, and will be important for investigations of corticogenesis and its disruption in embryonic mouse models.

Indexed as

AnimalsAnisotropyCerebral CortexDiffusion Magnetic Resonance ImagingFluorescent Antibody TechniqueImaging, Three-DimensionalMice, Inbred C57BLMicroscopyOrganogenesiscortexdevelopmentdiffusion MRImicroimagingmouse embryo

Identifiers

PMID24518754
PMCPMC4459293
OpenAlexW2135210816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.