Evidence map›Paper›PMID 24518752›Full record

Trial reportEuropean journal of clinical nutrition2014

Comparative effect of two Mediterranean diets versus a low-fat diet on glycaemic control in individuals with type 2 diabetes.

A Lasa, J Miranda, M Bulló, R Casas, J Salas-Salvadó, I Larretxi, R Estruch, V Ruiz-Gutiérrez, M P Portillo

Open access · bronzeAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 10 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 10 syntheses or guidelines pooled it, 181 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

A Lasa1] Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country-Lascaray Research Center, Vitoria, Spain [2] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III.
J Miranda1] Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country-Lascaray Research Center, Vitoria, Spain [2] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III.
M Bulló1] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III [2] Human Nutrition Unit, Hospital Universitari de Sant Joan, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
R Casas1] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III [2] Department of Internal Medicine, Institut \[dacute]Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain.
J Salas-Salvadó1] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III [2] Human Nutrition Unit, Hospital Universitari de Sant Joan, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
I LarretxiNutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country-Lascaray Research Center, Vitoria, Spain.
R Estruch1] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III [2] Department of Internal Medicine, Institut \[dacute]Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain.
V Ruiz-Gutiérrez1] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III [2] Nutrition and Lipids Metabolism, Instituto de la Grasa, Seville, Spain.
M P Portillo1] Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country-Lascaray Research Center, Vitoria, Spain [2] CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III.
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAlthough benefits have been attributed to the Mediterranean diet, its effect on glycaemic control has not been totally elucidated. The aim of this work was to compare the effect of two Mediterranean diets versus a low-fat diet on several parameters and indices related to glycaemic control in type 2 diabetic subjects. SUBJECTS/

methodsA multicentric parallel trial was conducted on 191 participants (77 men and 114 women) of the PREDIMED study in order to compare three dietary interventions: two Mediterranean diets supplemented with virgin olive oil (n=67; body mass index (BMI)=29.4±2.9) or mixed nuts (n=74; BMI=30.1±3.1) and a low-fat diet (n=50; BMI=29.8±2.8). There were no drop-outs. Changes in body weight and waist circumference were determined. Insulin resistance was measured by HOMA-IR index, adiponectin/leptin and adiponectin/HOMA-R ratios after 1 year of follow-up.

resultsIncreased values of adiponectin/leptin ratio (P=0.043, P=0.001 and P<0.001 for low-fat, olive oil and nut diets, respectively) and adiponectin/HOMA-IR ratio (P=0.061, P=0.027 and P=0.069 for low-fat, olive oil and nut diets, respectively) and decreased values of waist circumference (P=0.003, P=0.001 and P=0.001 for low-fat, olive oil and nut diets, respectively) were observed in the three groups. In both Mediterranean diet groups, but not in the low-fat diet group, this was associated with a significant reduction in body weight (P=0.347, P=0.003 and P=0.021 for low-fat, olive oil and nut diets, respectively).

conclusionsMediterranean diets supplemented with virgin olive oil or nuts reduced total body weight and improved glucose metabolism to the same extent as the usually recommended low-fat diet.

Indexed as

Diet, Fat-RestrictedDiet, MediterraneanInsulin ResistanceAdipokinesAdiponectinAgedBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2Dietary FatsFemaleHumansLeptinMaleMiddle AgedNutsAdipokinesAdiponectinBlood GlucoseDietary FatsLeptinOlive OilPlant Oils

Identifiers

PMID24518752
OpenAlexW1978714421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.