Evidence map›Paper›PMID 24518685›Full record

ArticlePolymer chemistry2014

PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses.

Eduardo Ruiz-Hernández, Michael Hess, Gustavo J Melen, Benjamin Theek, Marina Talelli, Yang Shi, Burcin Ozbakir, Erik A Teunissen, Manuel Ramírez, Diana Moeckel and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Eduardo Ruiz-Hernández *Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Michael Hess *Department of Biochemistry, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Gustavo J MelenDepartment of Hematooncology & Stem Cell Transplantation Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Benjamin TheekDepartment of Experimental Molecular Imaging, University Clinic and Helmholtz Center for Biomedical Engineering, Aachen, Germany.
Marina TalelliDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Yang ShiDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Burcin OzbakirDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Erik A TeunissenDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Manuel RamírezDepartment of Hematooncology & Stem Cell Transplantation Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Diana MoeckelDepartment of Experimental Molecular Imaging, University Clinic and Helmholtz Center for Biomedical Engineering, Aachen, Germany.
Fabian KiesslingDepartment of Experimental Molecular Imaging, University Clinic and Helmholtz Center for Biomedical Engineering, Aachen, Germany.
Gert StormDepartment of Controlled Drug Delivery, Targeted Therapeutics Section, University of Twente and MIRA Institute for Biomedical Engineering and Technical Medicine, Enschede, The Netherlands.
Hans W ScheerenDepartment of Organic Chemistry, Radboud Univ Nijmegen, Heyendaalse weg 135, 6525 AJ Nijmegen, The Netherlands.
Wim E HenninkDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Aladar A SzalayDepartment of Biochemistry, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Jochen StritzkerDepartment of Biochemistry, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Twan LammersDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLHospital Infantil Universitario Niño Jesús · ESFleet Science Center · USRadboud University Nijmegen · NLUniversity of California, San Diego · USUniversity of Twente · NLUniversity of Würzburg · DE

Funding

European Research Council 309495
6 · The paper itself

Abstract

An enzymatically activatable prodrug of doxorubicin was covalently coupled, using click-chemistry, to the hydrophobic core of poly(ethylene glycol)-

Identifiers

PMID24518685
PMCPMC3836408
OpenAlexW2102306106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.