ArticleBritish journal of cancer2014
Triaging borderline/mild dyskaryotic Pap cytology with p16/Ki-67 dual-stained cytology testing: cross-sectional and longitudinal outcome study.
Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up.International journal of cancer · 2018Trial
- Significance of Triple Detection of p16/ki-67 Dual-Staining, Liquid-Based Cytology and HR HPV Testing in Screening of Cervical Cancer: A Retrospective Study.Frontiers in oncology · 2022Article
- Evaluation of Cervical High-Grade Squamous Intraepithelial Lesions-Correlated Markers as Triage Strategy for Colposcopy After Co-Testing.OncoTargets and therapy · 2021Article
- Implementation of p16/Ki67 dual stain cytology in a Danish routine screening laboratory: Importance of adequate training and experience.Cancer medicine · 2020Article
- p16/Ki-67 dual-stained cytology used for triage in cervical cancer opportunistic screening.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Progress in immunocytochemical staining for cervical cancer screening.Cancer management and research · 2019Review
- Application of p16/Ki-67 dual-staining cytology in cervical cancers.Journal of Cancer · 2019Review
- Dual staining for p16/Ki67 is a more specific test than cytology for triage of HPV-positive women.Virchows Archiv : an international journal of pathology · 2018Observational
- Evaluation of p16/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- [Indications for p16/Ki-67 in cervical cytology].Der Pathologe · 2017Review
- [Modern biomarkers for precancerous lesions of the uterine cervix : Histological-cytological correlation and use].Der Pathologe · 2016Review
- p16/Ki-67 dual-stained cytology for detecting cervical (pre)cancer in a HPV-positive gynecologic outpatient population.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Observational
- Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women.Gynecologic oncology · 2016Article
- Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: a multicenter study in China.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen with borderline/mildly dyskaryotic (BMD) cytology smears are currently followed up with repeat testing at 6 and 18 months. The objective of this study is to analyse the cross-sectional and longitudinal performance of p16/Ki-67 dual-stained cytology for the detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+) and CIN2+ in women with BMD, and to compare the results with baseline human papillomavirus (HPV) testing.
methodsConventional Pap cytology specimens of 256 women with BMD were dual stained for p16/Ki-67 retrospectively, and compared with baseline HPV results and long-term follow-up results.
resultsp16/Ki-67 dual-stained cytology showed a sensitivity of 100%, a specificity of 64.4% and a negative predictive value (NPV) of 100.% for CIN3+. Human papillomavirus testing demonstrated similar sensitivity (96.3%), and NPV (99.1%), but a significantly lower specificity (57.6%; P=0.024) for CIN3+. Sensitivity, specificity and NPV for CIN2+ of dual-stained cytology were 89.7%, 73.1% and 95.1%, respectively, which was similar when compared with HPV testing. Dual-stained cytology showed a significant lower referral rate than HPV testing (43.6% vs 49.1%; P=0.043). During long-term follow-up, no CIN3+ lesions developed in HPV-positive, dual-stained negative women.
conclusionsComparable sensitivity and NPV of dual-stained cytology for CIN3+, combined with a significantly higher specificity, makes p16/Ki-67 dual-stained cytology a viable alternative to HPV testing for triaging BMD.
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