Evidence map›Paper›PMID 24518561›Full record

ArticleTherapeutic drug monitoring2014

Risk of neurobehavioral disinhibition in prenatal methamphetamine-exposed young children with positive hair toxicology results.

Sarah K Himes, Linda L LaGasse, Chris Derauf, Elana Newman, Lynne M Smith, Amelia M Arria, Sheri A Della Grotta, Lynne M Dansereau, Beau Abar, Charles R Neal and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic drug monitoring, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Sarah K Himes*Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; †Department of Pediatrics, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI; ‡Division of Community Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; §Department of Psychology, The University of Tulsa, Tulsa, Oklahoma; ¶Department of Pediatrics, LABioMed Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, California; ‖Department of Family Science, Center on Young Adult Health and Development, University of Maryland School of Public Health, College Park, Maryland; **Department of Emergency Medicine and Psychiatry, University of Rochester Medical Center, Rochester, New York; and ††Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Linda L LaGasse
Chris Derauf
Elana Newman
Lynne M Smith
Amelia M Arria
Sheri A Della Grotta
Lynne M Dansereau
Beau Abar
Charles R Neal
Barry M Lester
Marilyn A Huestis
Brown University · USNational Institute on Drug Abuse · USWomen & Infants Hospital of Rhode Island · USMayo Clinic · USUCLA Medical Center · USUniversity of Hawaiʻi at Mānoa · USUniversity of Maryland, College Park · USUniversity of Rochester Medical Center · USUniversity of Tulsa · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
WILLINGNESS OF PRIMARY CARE PHYSICIANS TO ADOPT HANDHELD COMPUTINGP20RR011091 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI ERDEM, GULIZ · 1995 to 2009
$16.5M
Prental Methamphetamine Exposure and Child DevelopmentR01DA014948 · NIDA · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M. · 2001 to 2013
$14.5M
Detection Of Drugs Of Abuse In Alternative Biological Fluids And TissuesZIADA000412 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SCHEIDWEILER, KARL · 2009 to 2016
$3.9M
Monitoring In Utero Drug ExposureZIADA000433 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SCHEIDWEILER, KARL · 2009 to 2016
$2.9M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
Intramural NIH HHS Z99 DA999999NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCRR NIH HHS 5P20RR11091NCRR NIH HHS P20 RR011091NIDA NIH HHS R01 DA014948NIDA NIH HHS R01DA014948
6 · The paper itself

Abstract

backgroundThe objective was to evaluate the effects of prenatal methamphetamine exposure (PME) and postnatal drug exposures identified by child hair analysis on neurobehavioral disinhibition at 6.5 years of age.

methodsMother-infant pairs were enrolled in the Infant Development, Environment, and Lifestyle (IDEAL) Study in Los Angeles, Honolulu, Tulsa, and Des Moines. PME was determined by maternal self-report and/or positive meconium results. At the 6.5-year follow-up visit, hair was collected and analyzed for methamphetamine, tobacco, cocaine, and cannabinoid markers. Child behavioral and executive function test scores were aggregated to evaluate child neurobehavioral disinhibition. Hierarchical linear regression models assessed the impact of PME, postnatal substances, and combined PME with postnatal drug exposures on the child's neurobehavioral disinhibition aggregate score. Past year caregiver substance use was compared with child hair results.

resultsA total of 264 children were evaluated. Significantly more PME children (n = 133) had hair positive for methamphetamine/amphetamine (27.1% versus 8.4%) and nicotine/cotinine (38.3% versus 25.2%) than children without PME (n = 131). Overall, no significant differences in analyte hair concentrations were noted between groups. Significant differences in behavioral and executive function were observed between children with and without PME. No independent effects of postnatal methamphetamine or tobacco exposure, identified by positive hair test, were noted and no additional neurobehavioral disinhibition was observed in PME children with postnatal drug exposures, as compared with PME children without postnatal exposure.

conclusionsChild hair testing offered a noninvasive means to evaluate postnatal environmental drug exposure, although no effects from postnatal drug exposure alone were seen. PME, alone and in combination with postnatal drug exposures, was associated with behavioral and executive function deficits at 6.5 years.

Indexed as

Amphetamine-Related DisordersCase-Control StudiesChildChild DevelopmentCocaineFemaleHairHumansMethamphetamineMothersNicotianaNicotinePregnancyPrenatal Exposure Delayed EffectsRiskCocaineMethamphetamineNicotine

Identifiers

PMID24518561
PMCPMC4101149
OpenAlexW2317444814

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.