Evidence map›Paper›PMID 24518549›Full record

ArticleIranian biomedical journal2014

Influence of iron deficiency anemia on hemoglobin A1c levels in diabetic individuals with controlled plasma glucose levels.

Alap L Christy, Poornima A Manjrekar, Ruby P Babu, Anupama Hegde, M S Rukmini

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In one paragraph

Article in Iranian biomedical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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  13. Study of Correlation of HbA1c with Anemia in Pregnancy.Journal of obstetrics and gynaecology of India · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alap L ChristyDept. of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Bejai Mangalore 575004, India.
Poornima A ManjrekarDept. of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Bejai Mangalore 575004, India.
Ruby P BabuDept. of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Bejai Mangalore 575004, India.
Anupama HegdeDept. of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Bejai Mangalore 575004, India.
M S RukminiDept. of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Bejai Mangalore 575004, India.
Kasturba Medical College, Manipal · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHemoglobin A1C (HbA1c) reflects patient's glycemic status over the previous 3 months. Previous studies have reported that iron deficiency may elevate A1C concentrations, independent of glycemia. This study is aimed to analyze the effect of iron deficiency anemia on HbA1c levels in diabetic population having plasma glucose levels in control.

methodsTotally, 120 diabetic, iron-deficient anemic individuals (70 females and 50 males) having controlled plasma glucose levels with same number of iron-sufficient non-anemic individuals were streamlined for the study. Their data of HbA1c (Bio-Rad D-10 HPLC analyzer), ferritin (cobas e411 ECLIA hormone analyzer), fasting plasma glucose (FPG, Roche Hitachi P800/917 chemistry analyzer), hemoglobin (Beckman Coulter LH780), peripheral smear examination, red cell indices, and medical history were recorded. Statistical analysis was carried out by student's t-test, Chi-square test, and Pearson's coefficient of regression.

resultsWe found elevated HbA1c (6.8 ± 1.4%) in iron-deficient individuals as compared to controls, and elevation was more in women (7.02 ± 1.58%). On further classification on the basis of FPG levels, A1C was elevated more in group having fasting glucose levels between 100-126 mg/dl (7.33 ± 1.55%) compared to the those with normal plasma glucose levels (<100 mg/dl). No significant correlation was found between HbA1c and ferritin and hemoglobin.

conclusionThis study found a positive correlation between iron deficiency anemia and increased A1C levels, especially in the controlled diabetic women and individuals having FPG between 100-126 mg/dl. Hence, before altering the treatment regimen for diabetic patient, presence of iron deficiency anemia should be considered.

Indexed as

AdultAgedAnemia, Iron-DeficiencyBlood GlucoseDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansMaleMiddle AgedBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanDiabetesHemoglobin A1CIron deficiency anemia

Identifiers

PMID24518549
PMCPMC3933917
OpenAlexW2125174356

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.