Evidence map›Paper›PMID 24518291›Full record

ReviewCoronary artery disease2014

A controversial step forward: A commentary on the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults.

Philip A Ades

Erratum issuedAbstract readReview
In one paragraph

Review in Coronary artery disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. COVID-19: Molecular and Cellular Response.Frontiers in cellular and infection microbiology · 2021
    Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

1 author.

Philip A AdesDivision of Cardiology, University of Vermont College of Medicine, Fletcher Allen Health Care, Burlington, Vermont, USA.

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KHADANGA, SHERRIE · 2013 to 2022
$21.3M
NIGMS NIH HHS P20 GM103644NIGMS NIH HHS P20GM103644-01
6 · The paper itself

Abstract

The 2013 ACC/AHA guidelines on the treatment of blood cholesterol in adults is a major step forward in the field of preventive cardiology but it is not without controversy. It should be well accepted that in individuals with established atherosclerotic vascular disease, individuals with a low-density lipoprotein cholesterol of greater than 190 mg/dl and individuals with diabetes, treatment with an appropriate fixed dose of a statin, without titration to a specific low-density lipoprotein goal, will provide substantial protection against future atherosclerotic vascular disease events. More controversial is the utilization of a risk calculator in primary care to determine which individuals will require a statin. For as long as these risk calculators are in question, primary care practitioners will struggle to make treatment decisions. Factors such as cardiovascular fitness, measures of adiposity, and details of the family history will aid in treatment decisions.

Indexed as

American Heart AssociationAnticholesteremic AgentsAtherosclerosisBiomarkersCardiologyCholesterolDecision Support TechniquesEvidence-Based MedicineHumansHypercholesterolemiaPatient SelectionPractice Guidelines as TopicRisk AssessmentRisk FactorsSocieties, MedicalTreatment OutcomeAnticholesteremic AgentsBiomarkersCholesterol

Identifiers

PMID24518291
PMCPMC4107357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.