ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Hippocampal neurogenesis in adult primates: a systematic review.Molecular psychiatry · 2025Pooled it
- Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour.Molecular psychiatry · 2023Pooled it
- Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells.ACS chemical neuroscience · 2026Article
- Social Behavior and Neurogenesis.International journal of molecular sciences · 2026Review
- Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice.EMBO reports · 2025Article
- Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.CNS neuroscience & therapeutics · 2025Article
- Adult Hippocampal Neurogenesis as a Therapeutic Target in Fetal Alcohol Spectrum Disorder.Advances in experimental medicine and biology · 2025Review
- GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice.Cell & bioscience · 2024Article
- Effect of Escitalopram on the Number of DCX-Positive Cells and NMUR2 Receptor Expression in the Rat Hippocampus under the Condition of NPSR Receptor Blockade.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- A Baboon Brain Atlas for Magnetic Resonance Imaging and Positron Emission Tomography Image Analysis.Frontiers in neuroanatomy · 2021Article
- Chronic Inhibition of FAAH Reduces Depressive-Like Behavior and Improves Dentate Gyrus Proliferation after Chronic Unpredictable Stress Exposure.Behavioural neurology · 2021Article
- The Pro-neurogenic Effects of Cannabidiol and Its Potential Therapeutic Implications in Psychiatric Disorders.Frontiers in behavioral neuroscience · 2020Review
- Young at heart: Insights into hippocampal neurogenesis in the aged brain.Behavioural brain research · 2019Review
- Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset.Molecular brain · 2019Article
- The Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis.Brain sciences · 2019Review
- Validation of hippocampal biomarkers of cumulative affective experience.Neuroscience and biobehavioral reviews · 2019Review
- Psychosocial Pathways to Racial/Ethnic Inequalities in Late-Life Memory Trajectories.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019Article
- Perspective: Of Mice and Men - How Widespread Is Adult Neurogenesis?Frontiers in neuroscience · 2019Article
- Arab American Cognitive Aging: Opportunities for Advancing Research on Alzheimer's Disease Disparities.Innovation in aging · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Adult hippocampal neurogenesis is critically implicated in rodent models of stress and anxiety as well as behavioral effects of antidepressants. Whereas similar factors such as psychiatric disorder and antidepressant administration are correlated with hippocampal volume in humans, the relationship between these factors and adult neurogenesis is less well understood. To better bridge the gap between rodent and human physiology, we examined the numbers of proliferating neural precursors and immature cells in the hippocampal dentate gyrus (DG) as well as in vivo magnetic resonance imaging (MRI)-estimated whole hippocampal volume in eight socially dominant- or subordinate-like (SL) baboons administered the antidepressant fluoxetine or vehicle. SL baboons had lower numbers of proliferating cells and immature neurons than socially dominant-like baboons. Fluoxetine treatment was associated with a larger whole hippocampal volume but surprisingly resulted in lower numbers of immature neurons. These findings are the first to indicate that adult neurogenesis in the baboon hippocampal DG may be functionally relevant in the context of social stress and mechanisms of antidepressant action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.