Evidence map›Paper›PMID 24518113›Full record

ArticleThe Journal of investigative dermatology2014

PHIPing out: a genetic basis for tumor ulceration.

Jack L Arbiser

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jack L ArbiserDepartment of Dermatology, Winship Cancer Institute, Atlanta and Atlanta Veterans Administration Hospital, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: jarbise@emory.edu.
Emory University · US

Funding

Cutaneous Hemangiomas and Signal TransductionR01AR047901 · NIAMS · EMORY UNIVERSITY · PI ARBISER, JACK L · 2001 to 2018
$4.3M
UV light and the cutaneous neurosensory systemP30AR042687 · NIAMS · EMORY UNIVERSITY · PI CAUGHMAN, STEWART W · 1994 to 2003
$2.5M
NIAMS NIH HHS P30 AR042687NIAMS NIH HHS P30 AR42687NIAMS NIH HHS R01 AR047901NIAMS NIH HHS R01 AR47901
6 · The paper itself

Abstract

Ulceration is a common negative prognostic marker of solid tumors including melanoma. The signaling basis of ulceration is being elucidated. PHIP has been found to be amplified in wild-type melanomas, resulting in Akt activation and aerobic glycolysis (Warburg effect), associated with ulceration. The ulceration phenotype likely represents the genotype of the reactive oxygen driven tumor, in which reactive oxygen drives angiopoietin-2 production, tumor growth, and invasion. This phenotype is amenable to pharmacologic intervention.

Indexed as

AnimalsFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMelanomaSkin NeoplasmsSkin UlcerIntracellular Signaling Peptides and ProteinsPHIP protein, human

Identifiers

PMID24518113
PMCPMC4412359
OpenAlexW2082924022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.