ArticleAntiviral therapy2014
Association between systemic inflammation and obstructive sleep apnea in men with or at risk for HIV infection.
Article in Antiviral therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Obstructive sleep apnea-related hypoxemia and heart rate dynamics are associated with systemic inflammation in people living with HIV.Sleep & breathing = Schlaf & Atmung · 2026Article
- Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV.AIDS (London, England) · 2025Article
- Variations in the sleep-related breathing disorder index on polysomnography between men with HIV and controls: a matched case-control study.BMC infectious diseases · 2024Article
- Sleep deficiency among people living with human immunodeficiency virus: A growing challenge.HIV medicine · 2024Review
- Immune Reconstitution Inflammatory Syndrome Due to HIV Treatment as a Potential Trigger: A Case Report with Late-Onset Narcolepsy.Nature and science of sleep · 2024Article
- Viruses and Endocrine Diseases.Microorganisms · 2023Review
- Sleep Disturbances and Chronic Pain in People with HIV: Implications for HIV-Associated Neurocognitive Disorders.Current sleep medicine reports · 2022Article
- Diagnostic performance of screening tools for the detection of obstructive sleep apnea in people living with HIV.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Pathogenesis of obstructive sleep apnea in people living with HIV.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Article
- The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa.Frontiers in immunology · 2021Review
- Monocytic C-C chemokine receptor 5 expression increases in in vitro intermittent hypoxia condition and in severe obstructive sleep apnea patients.Sleep & breathing = Schlaf & Atmung · 2019Article
- Insulin Resistance is Associated with Higher Plasma Viral Load Among HIV-Positive Adults Receiving Longer-Term (1 Year) Combination Antiretroviral Therapy (ART).Journal of infectious disease and therapy · 2019Article
- Sleep and neuropsychological performance in HIV+ subjects on efavirenz-based therapy and response to switch in therapy.HIV clinical trials · 2018Article
- A Wake-up Call for Human Immunodeficiency Virus (HIV) Providers: Obstructive Sleep Apnea in People Living With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Observational
- Association of Markers of Inflammation with Sleep and Physical Activity Among People Living with HIV or AIDS.AIDS and behavior · 2015Article
- Prevalence and correlates of obstructive sleep apnoea among patients with and without HIV infection.HIV medicine · 2015Observational
- Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy.Diabetes care · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe sought to determine whether markers of systemic inflammation are associated with the presence of moderate/severe obstructive sleep apnea (OSA) and whether this association differs based on HIV and HIV treatment status.
methodsHIV-uninfected men (HIV-; n=60), HIV-infected men receiving HAART (HIV+/HAART; n=58) and HIV-infected men not receiving HAART (HIV+/no HAART; n=41) underwent polysomnograpy and measurement of plasma levels of tumour necrosis factor (TNF)-α, soluble TNF-α receptors I and II (sTNFRI and sTNFRII) and interleukin (IL)-6. The relationship between moderate/severe OSA (respiratory disturbance index ≥15 apnea/hypopnea events/h) and inflammatory markers was assessed with multivariable regression models.
resultsCompared with the HIV- men, HIV+/HAART men and HIV+/no HAART men had higher levels of TNF-α, sTNFRI and sTNFRII, independent of age, race, smoking status, obstructive lung disease (OLD) and body mass index (BMI). Moderate/severe OSA was present in 48% of the sample (HIV- 57%; HIV+/HAART 41%; HIV+/no HAART 44%). Among the HIV+/no HAART men, but not in the other groups, TNF-α, sTNFRII and IL-6 levels were higher in those with moderate/severe OSA compared to men with no/mild OSA after adjustment for age, race, smoking status, OLD and BMI. Within this group, the association of high TNF-α concentrations with moderate/severe OSA was also independent of CD4(+) T-cell count and plasma HIV RNA concentration.
conclusionsCompared with HIV+/HAART men and HIV- men, markers of systemic inflammation were higher in HIV+/no HAART men. In these men, TNF-α was significantly related to OSA, independent of HIV-related covariates.
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Registered trials
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