Evidence map›Paper›PMID 24517962›Full record

ArticleJournal of pediatric hematology/oncology2015

Myogenic tumors in nevoid Basal cell carcinoma syndrome.

Simone Hettmer, Lisa A Teot, Harry Kozakewich, Annette M Werger, Kimberly J Davies, Christopher D M Fletcher, Holcombe E Grier, Carlos Rodriguez-Galindo, Amy J Wagers

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of pediatric hematology/oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The current landscape of rhabdomyosarcomas: an update.Virchows Archiv : an international journal of pathology · 2020
    Review
  6. Review
  7. Article
  8. Article
  9. Different Response ofFrontiers in oncology · 2018
    Article
  10. Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Simone Hettmer*Department of Pediatric Oncology, Dana-Farber Cancer Institute †Division of Pediatric Hematology/Oncology, Boston Children's Hospital ¶Department of Pathology, Boston Children's Hospital ‡Howard Hughes Medical Institute §Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University ∥Joslin Diabetes Center #Department of Pathology, Brigham and Women's Hospital, Boston, MA.
Lisa A Teot
Harry Kozakewich
Annette M Werger
Kimberly J Davies
Christopher D M Fletcher
Holcombe E Grier
Carlos Rodriguez-Galindo
Amy J Wagers
Brigham and Women's Hospital · USHarvard University · USBoston Children's Hospital · USDana-Farber Cancer Institute · USHarvard Stem Cell Institute · USJoslin Diabetes Center · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

In mice, activated Hedgehog (Hh) signaling induces tumors with myogenic differentiation. In humans, hyperactive Hh signaling due to germline PATCHED1 (PTCH1) mutations has been linked to nevoid basal cell carcinoma syndrome (NBCCS). We report an embryonal rhabdomyosarcoma in a 16-month-old girl with NBCCS and review the literature on myogenic neoplasms in NBCCS, including 8 fetal rhabdomyomas and 3 rhabdomyosarcomas. Of note, 3 population studies, including 255 individuals with NBCCS aged 4 months to 87 years, did not identify any myogenic tumors. Thus, myogenic tumors in NBCCS are rare and include both rhabdomyosarcomas and fetal rhabdomyomas.

Indexed as

Basal Cell Nevus SyndromeFemaleHumansInfantMutationPatched-1 ReceptorPatched ReceptorsPrognosisReceptors, Cell SurfaceReview Literature as TopicRhabdomyosarcomaPatched-1 ReceptorPatched ReceptorsPTCH1 protein, humanPtch1 protein, mouseReceptors, Cell Surface

Identifiers

PMID24517962
PMCPMC4127382
OpenAlexW2331528907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.