ReviewImmunological reviews2014
Urinary cell mRNA profiles predictive of human kidney allograft status.
Review in Immunological reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts.PloS one · 2015Pooled it
- Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets.Nature communications · 2024Article
- Urinary SPP1 has potential as a non-invasive diagnostic marker for focal segmental glomerulosclerosis.FEBS open bio · 2023Article
- Identification of Renal Transplantation Rejection Biomarkers in Blood Using the Systems Biology Approach.Iranian biomedical journal · 2023Article
- Contemporary Biomarkers for Renal Transplantation: A Narrative Overview.Journal of personalized medicine · 2023Review
- Immune monitoring of allograft status in kidney transplant recipients.Frontiers in nephrology · 2023Review
- The Protective Role of Nrf2 in Renal Tubular Cells in Oxidised Low-Density Lipoprotein-Induced Fibrosis.Analytical cellular pathology (Amsterdam) · 2023Article
- Design and Methods of the Validating Injury to the Renal Transplant Using Urinary Signatures (VIRTUUS) Study in Children.Transplantation direct · 2021Article
- A Three-Gene Peripheral Blood Potential Diagnosis Signature for Acute Rejection in Renal Transplantation.Frontiers in molecular biosciences · 2021Article
- Tackling Chronic Kidney Transplant Rejection: Challenges and Promises.Frontiers in immunology · 2021Review
- Augmented transcripts of kidney injury markers and renin angiotensin system in urine samples of overweight young adults.Scientific reports · 2020Article
- Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction.International journal of molecular sciences · 2020Review
- An overview of frailty in kidney transplantation: measurement, management and future considerations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
- The Use of Donor-Derived Cell-Free DNA for Assessment of Allograft Rejection and Injury Status.Journal of clinical medicine · 2020Article
- Article
- Rapid Detection of Zika Virus in Urine Samples and Infected Mosquitos by Reverse Transcription-Loop-Mediated Isothermal Amplification.Scientific reports · 2018Article
- Biomarkers in renal transplantation: An updated review.World journal of transplantation · 2017Review
- Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study.Scientific reports · 2017Article
- Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.Transplantation · 2016Article
- Translational implications of endothelial cell dysfunction in association with chronic allograft rejection.Pediatric nephrology (Berlin, Germany) · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Kidney allograft status is currently characterized using the invasive percutaneous needle core biopsy procedure. The procedure has become safer over the years, but challenges and complications still exist including sampling error, interobserver variability, bleeding, arteriovenous fistula, graft loss, and even death. Because the most common type of acute rejection is distinguished by inflammatory cells exiting the intravascular compartment and gaining access to the renal tubular space, we reasoned that a kidney allograft may function as an in vivo flow cytometer and sort cells involved in rejection into urine. To test this idea, we developed quantitative polymerase chain reaction (PCR) assays for absolute quantification of mRNA and pre-amplification protocols to overcome the low RNA yield from urine. Here, we review our single center urinary cell mRNA profiling studies that led to the multicenter Clinical Trials in Organ Transplantation (CTOT-04) study and the discovery and validation of a 3-gene signature of 18S rRNA-normalized measures of CD3ε mRNA and IP-10 mRNA and 18S rRNA that is diagnostic and predictive of acute cellular rejection in the kidney allograft. We also review our development of a 4-gene signature of mRNAs for vimentin, NKCC2, E-cadherin, and 18S rRNA diagnostic of interstitial fibrosis/tubular atrophy (IF/TA).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.