Evidence map›Paper›PMID 24517430›Full record

ReviewImmunological reviews2014

Inflammatory triggers of acute rejection of organ allografts.

Daniel N Mori, Daniel Kreisel, James N Fullerton, Derek W Gilroy, Daniel R Goldstein

Abstract readReview
In one paragraph

Review in Immunological reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 139 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Analysis of Rejection, Infection and Surgical Outcomes in Type I Versus Type II Diabetic Recipients After Simultaneous Pancreas-Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Multiple Shades of Gray-Macrophages in Acute Allograft Rejection.International journal of molecular sciences · 2023
    Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Daniel N MoriDepartments of Internal Medicine and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Daniel Kreisel
James N Fullerton
Derek W Gilroy
Daniel R Goldstein
University College London · GBYale University · USWashington University in St. Louis · US

Funding

Vascular Training GrantT32HL007950 · NHLBI · YALE UNIVERSITY · PI JEFFREY R. BENDER, Daniel Greif · 2000 to 2026
$9.6M
Mechanisms to augment primary immunity in agingR01AG028082 · NIA · YALE UNIVERSITY · PI DENG, JANE C · 2007 to 2023
$6.9M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
Role of Innate Immunity in Transplantation ToleranceR01AI064660 · NIAID · YALE UNIVERSITY · PI GOLDSTEIN, DANIEL ROBERT · 2006 to 2010
$1.7M
MECHANISMS OF LUNG ALLOGRAFT ACCEPTANCER01HL113931 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, KRUPNICK, ALEXANDER S. · 2012 to 2015
$1.5M
Aging, Viral Immunity and AtherosclerosisK02AG033049 · NIA · YALE UNIVERSITY · PI GOLDSTEIN, DANIEL ROBERT · 2008 to 2012
$737k
Hyaluronan as an innate ligand that induces inflammation after transplantationR21AI098108 · NIAID · YALE UNIVERSITY · PI GOLDSTEIN, DANIEL ROBERT · 2012 to 2013
$445k
Nanotherapeutics for combined immunesuppression in organ transplantationR21AI101918 · NIAID · YALE UNIVERSITY · PI FAHMY, TAREK, GOLDSTEIN, DANIEL ROBERT · 2013 to 2014
$433k
NHLBI NIH HHS HL094601NHLBI NIH HHS HL113931NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL113931NHLBI NIH HHS T32HL007950NIAID NIH HHS AI098108NIAID NIH HHS AI101918NIAID NIH HHS R01 AI064660NIAID NIH HHS R21 AI098108NIAID NIH HHS R21 AI101918NIA NIH HHS AG028082NIA NIH HHS AG033049NIA NIH HHS K02 AG033049NIA NIH HHS R01 AG028082Wellcome Trust 087520
6 · The paper itself

Abstract

Solid organ transplantation is a vital therapy for end stage diseases. Decades of research have established that components of the adaptive immune system are critical for transplant rejection, but the role of the innate immune system in organ transplantation is just emerging. Accumulating evidence indicates that the innate immune system is activated at the time of organ implantation by the release of endogenous inflammatory triggers. This review discusses the nature of these triggers in organ transplantation and also potential mediators that may enhance inflammation resolution after organ implantation.

Indexed as

Signal TransductionAllograftsAnimalsGraft RejectionHumansImmunity, InnateInflammationInflammation MediatorsOrgan TransplantationTreatment OutcomeInflammation Mediatorsinflammationorgan transplantationresolution

Identifiers

PMID24517430
PMCPMC3939032
OpenAlexW2120569077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.