ReviewImmunological reviews2014
Transplantation tolerance: from theory to clinic.
Review in Immunological reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- In vivo chimeric antigen receptor (CAR)-T cell therapy.Nature reviews. Drug discovery · 2026Review
- Hematopoietic stem cell microtransplantation: current situation and challenges.Therapeutic advances in hematology · 2025Review
- Metabolically Glycoengineered Neural Stem Cells Boost Neural Repair After Cardiac Arrest.Advanced functional materials · 2024Article
- Immunopathology of lung transplantation: from infection to rejection and vice versa.Frontiers in immunology · 2024Review
- Dexamethasone priming enhances stemness and immunomodulatory property of tissue-specific human mesenchymal stem cells.BMC developmental biology · 2021Article
- Progress in Liver Transplant Tolerance and Tolerance-Inducing Cellular Therapies.Frontiers in immunology · 2020Review
- Innate Immune Determinants of Graft-Versus-Host Disease and Bidirectional Immune Tolerance in Allogeneic Transplantation.OBM transplantation · 2019Article
- Cooperation of CD4Experimental and therapeutic medicine · 2018Article
- Technique for orthotopic liver transplantation in cynomolgus monkeys (Macaca fascicularis).Annals of surgical treatment and research · 2018Article
- Young donor white blood cell immunotherapy induces extensive tumor necrosis in advanced-stage solid tumors.Heliyon · 2017Article
- Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.Cellular & molecular immunology · 2017Review
- Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance.Current transplantation reports · 2017Review
- Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment.International journal of endocrinology · 2017Article
- 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.Nature medicine · 2016Article
- BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor.Acta pharmacologica Sinica · 2016Article
- T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.Nature immunology · 2015Article
- The role of donor-derived veto cells in nonmyeloablative haploidentical HSCT.Bone marrow transplantation · 2015Article
- Human mesenchymal stromal cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation.Stem cells (Dayton, Ohio) · 2015Article
- Banking on iPSC--is it doable and is it worthwhile.Stem cell reviews and reports · 2015Article
- Transplantation: moving to the next level.Immunological reviews · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Tolerance induction and alloreactivity can be applied to the clinic for the transplantation of solid organs and in the treatment of human cancers respectively. Hematopoietic chimerism, the stable coexistence of host and donor blood cells, guarantees that a solid organ from the same donor will be tolerated without a requirement for maintenance immunosuppression, and it also serves as a platform for the adoptive immunotherapy of hematologic malignancies using donor lymphocyte infusions. This review focuses on clinically relevant methods for inducing hematopoietic chimerism and transplantation tolerance, with a special emphasis on reduced intensity transplantation conditioning and high dose, post-transplantation cyclophosphamide to prevent graft rejection and graft-versus-host disease (GVHD). Reduced intensity transplantation regimens permit a transient cooperation between donor and host immune systems to eradicate malignancy without producing GVHD. Their favorable toxicity profile also enables the application of allogeneic stem cell transplantation to treat non-malignant disorders of hematopoiesis and to induce tolerance for solid organ transplantation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.