Evidence map›Paper›PMID 24516797›Full record

ArticleAnnals of cardiothoracic surgery2014

Rationale and design of the Left Atrial Appendage Occlusion Study (LAAOS) III.

Richard Whitlock, Jeff Healey, Jessica Vincent, Kate Brady, Kevin Teoh, Alistair Royse, Pallav Shah, Yingqiang Guo, Marco Alings, Richard J Folkeringa and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of cardiothoracic surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Heart Failure and Stroke: A Narrative Review.Journal of clinical medicine · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Left atrial appendage exclusion in atrial fibrillation.Frontiers in cardiovascular medicine · 2022
    Review
  13. First-line treatment of persistent and long-standing persistent atrial fibrillation with single-stage hybrid ablation: a 2-year follow-up study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Use of left atrial appendage occlusion among older cardiac surgery patients with preoperative atrial fibrillation: a national cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Richard WhitlockDepartment of Surgery, McMaster University, Hamilton, Canada ; ; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada ;
Jeff HealeyPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada ; ; Department of Medicine, McMaster University, Hamilton, Canada ;
Jessica VincentPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada ;
Kate BradyPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada ;
Kevin TeohDepartment of Surgery, McMaster University, Hamilton, Canada ; ; Department of Surgery, Southlake Regional Health Centre, Newmarket, Canada ;
Alistair RoyseDepartment of Surgery, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia ;
Pallav ShahDepartment of Cardiothoracic Surgery, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia ;
Yingqiang GuoDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China ;
Marco AlingsDepartment of Cardiology and Electrophysiology, Amphia Ziekenhuis, Breda, the Netherlands ;
Richard J FolkeringaDepartment of Cardiology, Medical Center Leeuwarden, Leeuwarden, the Netherlands ;
Domenico PaparellaDivision of Cardiac Surgery, Department of Emergency and Organ Transplant (DETO), University of Bari Aldo Moro, Bari, Italy ;
Andrea ColliDepartment of Cardiology, Thoracic and Vascular Sciences, University of Padova, Padova, Italy ;
Steven R MeyerDepartment of Surgery, University of Alberta, Edmonton, Canada ;
Jean-François LegareDivision of Cardiac Surgery, Dalhousie University, Halifax, Canada ;
François LamontagneCentre de recherché Clinique Étienne-Lebel and Faculté de Médecine et des Sciences de la Santé, Univesité de Sherbrooke, Sherbrooke, Canada ;
Wilko ReentsDepartment of Cardiac Surgery, Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany ;
Andreas BöningDepartment of Cardiovascular Surgery, University of Giessen, Giessen, Germany.
Stuart ConnollyPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada ; ; Department of Medicine, McMaster University, Hamilton, Canada ;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOcclusion of the left atrial appendage (LAA) is a promising approach to stroke prevention in atrial fibrillation (AF). However, evidence of its efficacy and safety to date is lacking. We herein describe the rationale and design of a definitive LAA occlusion trial in cardiac surgical patients with AF.

methodsWe plan to randomize 4,700 patients with AF in whom on-pump cardiac surgical procedure is planned to undergo LAA occlusion or no LAA occlusion. The primary outcome is the first occurrence of stroke or systemic arterial embolism over a mean follow-up of four years. Other outcomes include total mortality, operative safety outcomes (chest tube output in the first post-operative 24 hours, rate of post-operative re-exploration for bleeding in the first 48 hours post-surgery and 30-day mortality), re-hospitalization for heart failure, major bleed, and myocardial infarction.

resultsLeft Atrial Appendage Occlusion Study (LAAOS) III is funded in a vanguard phase by the Canadian Institutes for Health Research (CIHR), the Canadian Network and Centre for Trials Internationally, and the McMaster University Surgical Associates. As of September 9, 2013, 162 patients have been recruited into the study.

conclusionsLAAOS III will be the largest trial to explore the efficacy of LAA occlusion for stroke prevention. Its results will lead to a better understanding of stroke in AF and the safety and efficacy of surgical LAA occlusion.

Indexed as

Left atrial appendage (LAA)occlusionrandomized trialstroke

Identifiers

PMID24516797
PMCPMC3904329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.