Evidence map›Paper›PMID 24516755›Full record

ArticleSultan Qaboos University medical journal2014

Nasal Allergy and Otitis Media: A real correlation?

Desiderio Passali, Giulio C Passali, Maria Lauriello, Antonio Romano, Luisa Bellussi, Francesco M Passali

Open access · diamondAbstract read
In one paragraph

Article in Sultan Qaboos University medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Typmpanometric Findings Pre and Post Adenoidectomy Amongst Children with Obstructive Adenoid Enlargement.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  4. Sports audiology: Ear hygiene practices of gym users who wear earphones.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2021
    Article
  5. Allergy and Otitis Media in Clinical Practice.Current allergy and asthma reports · 2020
    Review
  6. Review
  7. Article
  8. Otitis media with effusion and atopy: is there a causal relationship?The World Allergy Organization journal · 2017
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Desiderio PassaliUniversità di Siena, Siena, Italy;
Giulio C PassaliUniversità Cattolica del Sacro Cuore, Rome, Italy;
Maria LaurielloUniversità degli Studi dell'Aquila, L'Aquila, Italy;
Antonio RomanoUniversità di Siena, Siena, Italy;
Luisa BellussiUniversità di Siena, Siena, Italy;
Francesco M PassaliUniversità degli Studi di Roma Tor Vergata, Rome, Italy.
University of Siena · ITUniversità Cattolica del Sacro Cuore · ITUniversity of L'Aquila · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe correlation between middle ear pathology and nasal allergy has been debated for almost 30 years. This study aimed to evaluate the relationship between otitis media with effusion (OME) and persistent allergic rhinitis symptoms versus intermittent rhinitis in children.

methodsThe study included 100 atopic children (52 boys, 48 girls) aged 5-9 years with otological symptoms who were patients of the University of Siena Hospital, Italy. Ear, nose and throat evaluations, tympanometry, skin prick tests (SPTs), mucociliary transport time (MCTt) and Eustachian tube function tests were performed.

resultsThe SPTs revealed 50 children sensitised to Dermatophagoides pteronyssinus, 34 to grass pollen and 16 to Parietaria. Of all patients, mild symptoms were intermittent in 19 children and persistent in 18; moderate/severe symptoms were intermittent in 22 and persistent in 41. Tubal dysfunction was present in 25 children, whereas middle ear effusion was present in 45 children undergoing myringotomy. The MCTt was slower in the persistent group (21 ± 2 mins) versus the intermittent group (16 ± 2 mins) with a significant difference (P <0.01). Mean eosinophil cationic protein (ECP) values in the middle ear effusions of children who had undergone myringotomy were 251 ± 175.2 μg/L, and mean ECP blood values were 25.5 ± 16.3 μg/L, with significant differences (P < 0.001).

conclusionThere was a significant association between OME, delayed MCTt, ECP values in middle ear effusion and persistent symptoms of allergic rhinitis. These results suggest a direct involvement of the middle ear mucosa as a target organ in persistent forms.

Indexed as

ChildrenEustachian TubesGenetic PredispositionItalyNasal AllergyOtitis Media

Identifiers

PMID24516755
PMCPMC3916278
OpenAlexW1599138373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.