ArticleEuropean journal of microbiology & immunology2011
What you eat is what you get: Novel Campylobacter models in the quadrangle relationship between nutrition, obesity, microbiota and susceptibility to infection.
Article in European journal of microbiology & immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Therapeutic and protective approaches to combatFrontiers in pharmacology · 2025Review
- Oral treatment of human gut microbiota associated IL-10Frontiers in microbiology · 2024Article
- Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota.Biomolecules · 2023Article
- Whole-Genome Shotgun Metagenomic Sequencing Reveals Distinct Gut Microbiome Signatures of Obese Cats.Microbiology spectrum · 2022Article
- The Host-Specific Intestinal Microbiota Composition ImpactsPathogens (Basel, Switzerland) · 2020Article
- Microbiome and biological blood marker changes in hens at different laying stages in conventional and cage free housings.Poultry science · 2020Article
- Novel ClinicalMicroorganisms · 2020Review
- Microbiota Features Associated With a High-Fat/Low-Fiber Diet in Healthy Adults.Frontiers in nutrition · 2020Article
- Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction byInternational journal of molecular sciences · 2019Article
- Impact ofInfection and immunity · 2019Article
- Investigating the Association Between the Caecal Microbiomes of Broilers andFrontiers in microbiology · 2018Article
- Influence of the Gut Microbiota Composition on Campylobacter jejuni Colonization in Chickens.Infection and immunity · 2017Article
- Campylobacter jejuni and associated immune mechanisms: short-term effects and long-term implications for infants in low-income countries.Current opinion in infectious diseases · 2017Review
- Microbiota Composition and Immune Responses DuringEuropean journal of microbiology & immunology · 2017Article
- Comprehensive Survey of Intestinal Microbiota Changes in Offspring of Human Microbiota-Associated Mice.European journal of microbiology & immunology · 2017Article
- More Pathogenicity or Just More Pathogens?-On the Interpretation Problem of Multiple Pathogen Detections with Diagnostic Multiplex Assays.Frontiers in microbiology · 2017Review
- Article
- The Role of IL-23, IL-22, and IL-18 in Campylobacter Jejuni Infection of Conventional Infant Mice.European journal of microbiology & immunology · 2016Article
- Toll-Like Receptor-4 Dependent Intestinal Gene Expression During Arcobacter Butzleri Infection of Gnotobiotic Il-10 Deficient Mice.European journal of microbiology & immunology · 2016Article
- Differences in host breed and diet influence colonization byGut pathogens · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterocolitis caused by Campylobacter jejuni-infections represents an important socioeconomic burden worldwide. Recent results from novel murine infection models reveal that the intestinal microbiota is essential for maintaining colonization resistance against C. jejuni. We extended these studies to investigate the role of nutrition and obesity in susceptibility to C. jejuni-infection. Gnotobiotic (GB) mice generated by antibiotic treatment, which were fed with a human cafeteria diet (CAF), as well as obese (ob/ob) mice with a conventional microbiota harbored higher Escherichia coli loads in their colon as compared to respective controls. Following oral infection, C. jejuni 43431 ATCC readily colonized the intestines of CAF and ob/ob mice, whereas GB mice fed with a standard chow (MUD) eradicated the pathogen within days. Furthermore, live C. jejuni translocated into mesenteric lymph nodes of CAF, but not MUD mice. Strikingly, stably infected animals developed enterocolitis as indicated by increased numbers of immune and apoptotic cells in the colon in situ. We conclude that a specific human diet and obesity render mice susceptible to C. jejuni infection. The corresponding murine models are excellently suited for the study of C. jejuni pathogenesis and will help to get further insights into interplays between C. jejuni, microbiota, diet, obesity and immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.