ArticleEuropean journal of microbiology & immunology2011
PerR controls peroxide- and iron-responsive expression of oxidative stress defense genes in Helicobacter hepaticus.
Article in European journal of microbiology & immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- How Microbes Defend Themselves From Incoming Hydrogen Peroxide.Frontiers in immunology · 2021Review
- Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2017Review
- Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.FEMS microbiology reviews · 2016Article
- The allosteric behavior of Fur mediates oxidative stress signal transduction in Helicobacter pylori.Frontiers in microbiology · 2015Article
- Impact of oxidative stress defense on bacterial survival and morphological change in Campylobacter jejuni under aerobic conditions.Frontiers in microbiology · 2015Article
- Regulation of oxidative stress resistance in Campylobacter jejuni, a microaerophilic foodborne pathogen.Frontiers in microbiology · 2015Review
- Metal-responsive gene regulation and metal transport in Helicobacter species.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2007Review
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic intestinal and hepatic colonization with the microaerophilic murine pathogen Helicobacter hepaticus can lead to a range of inflammatory diseases of the lower digestive tract. Colonization is associated with an active cellular immune response and production of oxygen radicals. During colonization, H. hepaticus needs to cope with and respond to oxidative stress, and here we report on the role of the H. hepaticus PerR-regulator (HH0942) in the expression of the peroxidase-encoding katA (HH0043) and ahpC (HH1564) genes. Transcription of katA and ahpC was induced by hydrogen peroxide, and by iron restriction of growth media. This iron- and hydrogen peroxide-responsive regulation of katA and ahpC was mediated at the transcriptional level, from promoters directly upstream of the genes. Inactivation of the perR gene resulted in constitutive, iron-independent high-level expression of the katA and ahpC transcripts and corresponding proteins. Finally, inactivation of the katA gene resulted in increased sensitivity of H. hepaticus to hydrogen peroxide and reduced aerotolerance. In H. hepaticus, iron metabolism and oxidative stress defense are intimately connected via the PerR regulatory protein. This regulatory pattern resembles that observed in the enteric pathogen Campylobacter jejuni, but contrasts with the pattern observed in the closely related human gastric pathogen Helicobacter pylori.
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