ArticleInterface focus2013
Coevolutionary diversification creates nested-modular structure in phage-bacteria interaction networks.
Article in Interface focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
- The interplay between ecological networks drives host-plasmid community dynamics.PLoS computational biology · 2026Article
- Host range of 30 novelmicroPublication biology · 2026Article
- Phage diversity mirrors bacterial strain diversity in the honey bee gut microbiota.Nature communications · 2025Article
- Microbial community structure is affected by phage-resistance associated increases in host density.FEMS microbiology ecology · 2025Article
- Isolation of phages infecting the zoonotic pathogenbioRxiv : the preprint server for biology · 2025Article
- Article
- Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes arising during coevolutionary dynamics.bioRxiv : the preprint server for biology · 2024Article
- The evolutionary adaptation of wood-decay macrofungi to host gymnosperms differs from that to host angiosperms.Ecology and evolution · 2024Article
- Mechanistic interactions as the origin of modularity in biological networks.Proceedings. Biological sciences · 2024Article
- Disentangling top-down drivers of mortality underlying diel population dynamics of Prochlorococcus in the North Pacific Subtropical Gyre.Nature communications · 2024Article
- Host-specific viral predation network on coral reefs.The ISME journal · 2024Article
- Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes arising during coevolutionary dynamics.Virus evolution · 2024Article
- The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy.iScience · 2023Review
- From kill the winner to eliminate the winner in open phage-bacteria systems.PLoS computational biology · 2022Article
- Growth rate determines prokaryote-provirus network modulated by temperature and host genetic traits.Microbiome · 2022Article
- Modeling Virus and Bacteria Populations in Europa's Subsurface Ocean.Life (Basel, Switzerland) · 2022Article
- Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails.Scientific reports · 2022Article
- Article
- How does feedback from phage infections influence the evolution of phase variation in Campylobacter?PLoS computational biology · 2021Article
- A New Pipeline for Designing Phage Cocktails Based on Phage-Bacteria Infection Networks.Frontiers in microbiology · 2021Article
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2 authors.
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Abstract
Phage and their bacterial hosts are the most diverse and abundant biological entities in the oceans, where their interactions have a major impact on marine ecology and ecosystem function. The structure of interaction networks for natural phage-bacteria communities offers insight into their coevolutionary origin. At small phylogenetic scales, observed communities typically show a nested structure, in which both hosts and phages can be ranked by their range of resistance and infectivity, respectively. A qualitatively different multi-scale structure is seen at larger phylogenetic scales; a natural assemblage sampled from the Atlantic Ocean displays large-scale modularity and local nestedness within each module. Here, we show that such 'nested-modular' interaction networks can be produced by a simple model of host-phage coevolution in which infection depends on genetic matching. Negative frequency-dependent selection causes diversification of hosts (to escape phages) and phages (to track their evolving hosts). This creates a diverse community of bacteria and phage, maintained by kill-the-winner ecological dynamics. When the resulting communities are visualized as bipartite networks of who infects whom, they show the nested-modular structure characteristic of the Atlantic sample. The statistical significance and strength of this observation varies depending on whether the interaction networks take into account the density of the interacting strains, with implications for interpretation of interaction networks constructed by different methods. Our results suggest that the apparently complex community structures associated with marine bacteria and phage may arise from relatively simple coevolutionary origins.
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