ArticleGut and liver2014
Is a preoperative assessment of the early recurrence of pancreatic cancer possible after complete surgical resection?
Article in Gut and liver, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Predicting recurrence patterns and outcomes following resection of pancreatic ductal adenocarcinoma: a contemporary real-world data cohort study.Annals of medicine and surgery (2012) · 2026Article
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- Postoperative early recurrence prediction of pancreatic cancer based on CT and pathomics.BMC gastroenterology · 2025Article
- Preoperative prediction for early recurrence in patients with pancreatic ductal adenocarcinoma: combining radiomics and abdominal fat analysis.BMC medical imaging · 2025Article
- Gaining a new angle on pancreas cancer: A pre-operative thrombelastographic parameter predicts recurrence and survival among patients with resected periampullary and pancreatic adenocarcinoma.American journal of surgery · 2024Article
- Pancreatectomy Induces Cancer-Promoting Neutrophil Extracellular Traps.Annals of surgical oncology · 2024Article
- Improving patient stratification and selection for curative-intent treatment in localized pancreatic cancer.Hepatobiliary surgery and nutrition · 2024Article
- Article
- Early Recurrence after Upfront Surgery for Pancreatic Ductal Adenocarcinoma.Current oncology (Toronto, Ont.) · 2023Article
- Regional lymph node metastasis detected on preoperative CT and/or FDG-PET may predict early recurrence of pancreatic adenocarcinoma after curative resection.Scientific reports · 2022Article
- Liver metastases in pancreatic ductal adenocarcinoma: a predictive model based on CT texture analysis.La Radiologia medica · 2022Article
- Molecular Characterization of Pancreatic Ductal Adenocarcinoma Using a Next-Generation Sequencing Custom-Designed Multigene Panel.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Plasma KRAS mutations predict the early recurrence after surgical resection of pancreatic cancer.Cancer biology & therapy · 2021Article
- Perioperative Predictors of Early Recurrence for Resectable and Borderline-Resectable Pancreatic Cancer.Cancers · 2021Article
- The ultimate preoperative C-reactive protein-to-albumin ratio is a prognostic factor for survival after pancreatic cancer resection.European journal of medical research · 2020Article
- Endoscopic ultrasound guided gastroenterostomy for efferent jeunal loop obstruction in a patient with previous pancreaticoduodenectomy and ascites.Endoscopy international open · 2020Article
- Predictors of postoperative early recurrence of extrahepatic bile duct cancer.Surgery today · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThe prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a prognostic indicator of recurrence and reduced overall survival. The aim of this study was to identify preoperative prognostic factors and to create a prognostic model able to assess the early recurrence risk for patients with resectable PAC.
methodsA series of 177 patients with PAC treated surgically at the St. Andrea Hospital of Rome between January 2003 and December 2011 were reviewed retrospectively. Univariate and multivariate analyses were utilized to identify preoperative prognostic indicators.
resultsA preoperative CA 19-9 level >228 U/mL, tumor size >3.1 cm, and the presence of pathological preoperative lymph nodes statistically correlated with early recurrence. Together, these three factors predicted the possibility of an early recurrence with 90.4% accuracy. The combination of these three preoperative conditions was identified as an independent parameter for early recurrence based on multivariate analysis (p=0.0314; hazard ratio, 3.9811; 95% confidence interval, 1.1745 to 15.3245).
conclusionsPAC patient candidates for surgical resection should undergo an assessment of early recurrence risk to avoid unnecessary and ineffective resection and to identify patients for whom palliative or alternative treatment may be the treatment of choice.
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