Evidence map›Paper›PMID 24516693›Full record

ArticleThe American journal of case reports2014

Sudden onset of coma in a 70-year-old woman with cryoglobulinemia.

Gennaro Pagano, Klara Komici, Grazia Daniela Femminella, Claudio de Lucia, Marta Ianniciello, Dario Leosco, Nicola Ferrara, Giuseppe Rengo

Abstract read
In one paragraph

Article in The American journal of case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Gennaro PaganoDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Klara KomiciDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Grazia Daniela FemminellaDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Claudio de LuciaDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Marta IannicielloEpilepsy Center, Department of Neurological Sciences, Federico II University of Naples, Naples, Italy.
Dario LeoscoDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Nicola FerraraDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy ; Division of Cardiology, "Salvatore Maugeri" Foundation - IRCCS - Institute of Telese Terme, Telese Terme (BN), Italy.
Giuseppe RengoDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy ; Division of Cardiology, "Salvatore Maugeri" Foundation - IRCCS - Institute of Telese Terme, Telese Terme (BN), Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

patientFemale, 70 FINAL DIAGNOSIS: Chronic Heaptitis C Symptoms: Coma Medication: - Clinical Procedure: Plamapheresis Specialty: Neurology.

objectiveUnusual clinical course.

backgroundHepatitis C Virus (HCV)-related chronic hepatitis can be associated with mixed cryoglobulinemia (MC). Although several MC cases have been described, the wide variety of symptoms often makes diagnosis challenging. CASE REPORT: We describe a sudden onset of coma in a 70-year-old woman with an undiagnosed chronic hepatitis C infection related to MC. Head CT did not show any important pathology. Laboratory tests showed leucocytosis, but it was not possible to identify any pathogenic microorganism. Examination of cerebrospinal fluid did not show any pathology. There was a strongly positive test result for rheumatoid factor (409 U/l) and hypocomplementemia (C4 0.04 g/l). Laboratory assay was positive for antibodies against HCV and HCV RNA. The cryoglobulins were positive and after treatment with plasmapheresis her conditions improved.

conclusionsIn this case, the cryoglobulins laboratory exam was very helpful for the diagnosis. This test could be considered in the early management of elderly patients with sudden onset of coma.

Indexed as

ChronicComaCryoglobulinemiaHepatitis CPlasmapheresis

Identifiers

PMID24516693
PMCPMC3917880
OpenAlexW2037949180

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