ArticlePloS one2014
A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- "OCT based retinal changes in amblyopia: A systematic review".Journal of optometryPooled it
- The assessment of posterior ocular structures in Turkish children with anisometropic amblyopia.BMC ophthalmology · 2026Article
- OCT Assessment of Deep Optic Nerve Head, Subfoveal Choroidal Thickness, and Retinal Layers in Unilateral Anisometropic Amblyopia.Beyoglu eye journal · 2026Article
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Article
- Pattern electroretinography response in amblyopic adults.International ophthalmology · 2024Article
- Evaluation of fixation characteristics in amblyopia using microperimetry.International ophthalmology · 2023Article
- Long-term effects of early/late-onset visual deprivation on macular and retinal nerve fibers layer structure: A pilot study.PloS one · 2023Article
- Fixation stability after surgical treatment of strabismus and biofeedback fixation training in amblyopic eyes.BMC ophthalmology · 2021Article
- Article
- Topographical profiles of macula and optic nerve head in concomitant strabismus patients as measured using OCT and CSLO.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Spectral-Domain Optical Coherence Tomographic Angiography in Children With Amblyopia.JAMA ophthalmology · 2017Observational
- Changes in macular parameters in different types of amblyopia: optical coherence tomography study.Clinical ophthalmology (Auckland, N.Z.) · 2017Article
- Interocular anatomical and visual functional differences in pediatric patients with unilateral cataracts.BMC ophthalmology · 2016Article
- Evaluation of the retinal ganglion cell and choroidal thickness in young Turkish adults with hyperopic anisometropic amblyopia.International ophthalmology · 2016Article
- New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies.International journal of molecular sciences · 2016Review
- CAN Optical Coherence Tomography redefine amblyopia?Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe purpose of this study was to evaluate the possible structural changes of the macula in patients with unilateral amblyopia using optical coherence tomography (OCT) image segmentation. PATIENTS AND
methods38 consecutive patients (16 male; mean age 32.4±17.6 years; range 6-67 years) with unilateral amblyopia were involved in this study. OCT examinations were performed with a time-domain OCT device, and a custom-built OCT image analysis software (OCTRIMA) was used for OCT image segmentation. The axial length (AL) was measured by a LenStar LS 900 device. Macular layer thickness, AL and manifest spherical equivalent refraction (MRSE) of the amblyopic eye were compared to that of the fellow eye. We studied if the type of amblyopia (strabismus without anisometropia, anisometropia without strabismus, strabismus with anisometropia) had any influence on macular layer thickness values.
resultsThere was significant difference between the amblyopic and fellow eyes in MRSE and AL in all subgroups. Comparing the amblyopic and fellow eyes, we found a statistically significant difference only in the thickness of the outer nuclear layer in the central region using linear mixed model analysis keeping AL and age under control (p = 0.032). There was no significant difference in interocular difference in the thickness of any macular layers between the subgroups with one-way between-groups ANCOVA while statistically controlling for interocular difference in AL and age.
conclusionsAccording to our results there are subtle changes in amblyopic eyes affecting the outer nuclear layer of the fovea suggesting the possible involvement of the photoreceptors. However, further studies are warranted to support this hypothesis.
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