ArticlePloS one2014
Comparative variation within the genome of Campylobacter jejuni NCTC 11168 in human and murine hosts.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Genomic insights into zoonotic transmission and antimicrobial resistance in Campylobacter jejuni from farm to fork: a one health perspective.Gut pathogens · 2022Review
- Genomic Analysis Reveals That Isolation Temperature on Selective Media Introduces Genetic Variation inPathogens (Basel, Switzerland) · 2022Article
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- Common Adaptive Strategies Underlie Within-Host Evolution of Bacterial Pathogens.Molecular biology and evolution · 2021Article
- Phase Variation During Host Colonization and Invasion byFrontiers in microbiology · 2021Review
- Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10mSphere · 2020Article
- Experimental Evolution ofFrontiers in microbiology · 2020Article
- Investigating Major RecurringFrontiers in cellular and infection microbiology · 2020Article
- Domestication of Campylobacter jejuni NCTC 11168.Microbial genomics · 2019Article
- PhasomeIt: an 'omics' approach to cataloguing the potential breadth of phase variation in the genus Campylobacter.Microbial genomics · 2018Article
- Convergent Amino Acid Signatures in Polyphyletic Campylobacter jejuni Subpopulations Suggest Human Niche Tropism.Genome biology and evolution · 2018Article
- SACCHARIS: an automated pipeline to streamline discovery of carbohydrate active enzyme activities within polyspecific families and de novo sequence datasets.Biotechnology for biofuels · 2018Article
- Phase-Variable Changes in the Position ofJournal of bacteriology · 2017Article
- Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C. jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains.Molecular microbiology · 2017Article
- Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections.Journal of clinical microbiology · 2017Review
- Genomic insights from whole genome sequencing of four clonal outbreak Campylobacter jejuni assessed within the global C. jejuni population.BMC genomics · 2016Article
- Genomic variations leading to alterations in cell morphology of Campylobacter spp.Scientific reports · 2016Article
- Motility defects in Campylobacter jejuni defined gene deletion mutants caused by second-site mutations.Microbiology (Reading, England) · 2015Article
- Article
- A new age in functional genomics using CRISPR/Cas9 in arrayed library screening.Frontiers in genetics · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacteriosis incited by C. jejuni is a significant enteric disease of human beings. A person working with two reference strains of C. jejuni National Collection of Type Cultures (NCTC) 11168 developed symptoms of severe enteritis including bloody diarrhea. The worker was determined to be infected by C. jejuni. In excess of 50 isolates were recovered from the worker's stool. All of the recovered isolates and the two reference strains were indistinguishable from each other based on comparative genomic fingerprint subtyping. Whole genome sequence analysis indicated that the worker was infected with a C. jejuni NCTC 11168 obtained from the American Type Culture Collection; this strain (NCTC 11168-GSv) is the genome sequence reference. After passage through the human host, major genetic changes including indel mutations within twelve contingency loci conferring phase variations were detected in the genome of C. jejuni. Specific and robust single nucleotide polymorphism (SNP) changes in the human host were also observed in two loci (Cj0144c, Cj1564). In mice inoculated with an isolate of C. jejuni NCTC 11168-GSv from the infected person, the isolate underwent further genetic variation. At nine loci, mutations specific to inoculated mice including five SNP changes were observed. The two predominant SNPs observed in the human host reverted in mice. Genetic variations occurring in the genome of C. jejuni in mice corresponded to increased densities of C. jejuni cells associated with cecal mucosa. In conclusion, C. jejuni NCTC 11168-GSv was found to be highly virulent in a human being inciting severe enteritis. Host-specific mutations in the person with enteritis occurred/were selected for in the genome of C. jejuni, and many were not maintained in mice. Information obtained in the current study provides new information on host-specific genetic adaptation by C. jejuni.
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