ArticlePloS one2014
The role of Purkinje-myocardial coupling during ventricular arrhythmia: a modeling study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Effects of Purkinje Fiber Conduction Block on Cardiac Pump Function: Computational Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- In silico assessment of arrhythmic risk following the implantation of engineered heart tissues in porcine hearts with varying infarct locations.PLoS computational biology · 2026Article
- Toward cardiac electrophysiology digital twins with an efficient open source scalable solver on GPU clusters.Scientific reports · 2026Article
- Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time.Heart international · 2026Review
- To reconnect or not reconnect distal Purkinje fibers, that is the question when modeling the Purkinje fiber network.Frontiers in physiology · 2025Article
- Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions.Frontiers in physiology · 2025Article
- Calcium arrhythmogenicity of Purkinje fibers: importance of the animal model.Frontiers in physiology · 2025Review
- Fast interactive simulations of cardiac electrical activity in anatomically accurate heart structures by compressing sparse uniform cartesian grids.Computer methods and programs in biomedicine · 2024Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Studying the Influence of Finite Element Mesh Size on the Accuracy of Ventricular Tachycardia Simulation.Reviews in cardiovascular medicine · 2023Article
- Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.Scientific reports · 2023Article
- Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- ELUCIDATING THE ROLE OF THE HIS-PURKINJE SYSTEM DURING LONG QT MEDIATED ARRHYTHMIAS.Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) · 2023Article
- Orientation of conduction velocity vectors on cardiac mapping surfaces.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Conduction delays across the specialized conduction system of the heart: Revisiting atrioventricular node (AVN) and Purkinje-ventricular junction (PVJ) delays.Frontiers in cardiovascular medicine · 2023Article
- Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts.Frontiers in physiology · 2023Article
- Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling - Insights From Computational Modelling.Frontiers in physiology · 2022Article
- Leadless biventricular left bundle and endocardial lateral wall pacing versus left bundle only pacing in left bundle branch block patients.Frontiers in physiology · 2022Article
- Preliminary Study: Learning the Impact of Simulation Time on Reentry Location and Morphology Induced by Personalized Cardiac Modeling.Frontiers in physiology · 2021Article
- Creation and application of virtual patient cohorts of heart models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
The Purkinje system is the fast conduction network of the heart which couples to the myocardium at discrete sites called Purkinje-Myocyte Junctions (PMJs). However, the distribution and number of PMJs remains elusive, as does whether a particular PMJ is functional. We hypothesized that the Purkinje system plays a role during reentry and that the number of functional PMJs affect reentry dynamics. We used a computer finite element model of rabbit ventricles in which we varied the number of PMJs. Sustained, complex reentry was induced by applying an electric shock and the role of the Purkinje system in maintaining the arrhythmia was assessed by analyzing phase singularities, frequency of activation, and bidirectional propagation at PMJs. For larger junctional resistances, increasing PMJ density increased the mean firing rate in the Purkinje system, the percentage of successful retrograde conduction at PMJs, and the incidence of wave break on the epicardium. However, the mean firing of the ventricles was not affected. Furthermore, increasing PMJ density above 13/[Formula: see text] did not alter reentry dynamics. For lower junctional resistances, the trend was not as clear. We conclude that Purkinje system topology affects reentry dynamics and conditions which alter PMJ density can alter reentry dynamics.
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