ArticlePloS one2014
Memory networks in tinnitus: a functional brain image study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Guideline
- Invariant structural and functional brain regions associated with tinnitus: A meta-analysis.PloS one · 2022Pooled it
- The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using (99m)Tc-ECD SPECT.European radiology · 2016Trial
- Distinct neural circuits processing pleasant and unpleasant sounds: an fMRI-based approach.BMC neuroscience · 2025Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study.Brain sciences · 2022Article
- Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study.The journal of headache and pain · 2021Article
- The Neural Mechanisms of Tinnitus: A Perspective From Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Review
- Arterial Spin Labeling Cerebral Perfusion Changes in Chronic Tinnitus With Tension-Type Headache.Frontiers in neurology · 2021Article
- Cerebral Blood Flow Difference Between Acute and Chronic Tinnitus Perception: A Perfusion Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- Glucose Control Has an Impact on Cerebral Blood Flow Alterations in Chronic Tinnitus Patients.Frontiers in neuroscience · 2020Article
- Increased Resting-State Cerebellar-Cerebral Functional Connectivity Underlying Chronic Tinnitus.Frontiers in aging neuroscience · 2018Article
- Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis.Frontiers in human neuroscience · 2017Article
- Factor Analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation to the Temporoparietal Junction for Tinnitus.Neural plasticity · 2016Article
- Emerging hubs in phantom perception connectomics.NeuroImage. Clinical · 2016Article
- The Relevance of Interoception in Chronic Tinnitus: Analyzing Interoceptive Sensibility and Accuracy.BioMed research international · 2015Article
- Alterations of Regional Cerebral Blood Flow in Tinnitus Patients as Assessed Using Single-Photon Emission Computed Tomography.PloS one · 2015Article
- Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus.Frontiers in neurology · 2015Review
- The investigation of semantic memory deficit in chronic tinnitus: a behavioral report.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledTinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. The network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. The objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls.
methodsTwenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). The severity of tinnitus was assessed using the "Tinnitus Handicap Inventory" (THI). The images were processed and analyzed using "Statistical Parametric Mapping" (SPM8).
resultsA significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE <0.05) was observed in patients with tinnitus compared with healthy controls. The average total THI score was 50.8+18.24, classified as moderate tinnitus.
conclusionIt was possible to identify significant changes in the limbic system of the brain perfusion in tinnitus patients with normal hearing, suggesting that central mechanisms, not specific to the auditory pathway, are involved in the pathophysiology of symptoms, even in the absence of clinically diagnosed peripheral changes.
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