ArticlePloS one2014
Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- ARHGAP39 plays an essential role in anxiety-like behavior and stress response.Translational psychiatry · 2026Article
- Cerebellar structure and function abnormalities in 16p11.2 microduplication mice.Brain communications · 2026Article
- The meningeal-cerebellar axis: a new perspective on cerebellar development.Cellular and molecular life sciences : CMLS · 2025Review
- The emergence of electrical activity in human brain organoids.Stem cell reports · 2025Review
- Stk24 deficiency causes disrupted hippocampal neurogenesis and anxiety-like behavior in mice.Communications biology · 2025Article
- Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.Molecular neurobiology · 2025Article
- Azilsartan Attenuates 3-Nitropropinoic Acid-Induced Neurotoxicity in Rats: The Role of IĸB/NF-ĸB and KEAP1/Nrf2 Signaling Pathways.Neurochemical research · 2024Article
- Comparison of the Response to the CXCR4 Antagonist AMD3100 during the Development of Retinal Organoids Derived from ES Cells and Zebrafish Retina.International journal of molecular sciences · 2022Article
- Influence of diurnal phase on behavioral tests of sensorimotor performance, anxiety, learning and memory in mice.Scientific reports · 2022Article
- Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.Cell reports · 2021Article
- The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation.Translational psychiatry · 2021Article
- Intrauterine growth restriction compromises cerebellar development by affecting radial migration of granule cells via the JamC/Pard3a molecular pathway.Experimental neurology · 2021Article
- Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex.Frontiers in neuroscience · 2021Article
- Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns.Science advances · 2019Article
- Cerebellar involvement in warts Hypogammaglobulinemia immunodeficiency myelokathexis patients: neuroimaging and clinical findings.Orphanet journal of rare diseases · 2019Article
- Large Scale Calcium Imaging of the Cerebellar Vermis During Sensory Stimulus Unravels Two Response's Components That Differ in Their Spatiotemporal Properties.Frontiers in systems neuroscience · 2019Article
- Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.Frontiers in behavioral neuroscience · 2019Article
- NPTX2 is a key component in the regulation of anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Neuronal Migration During Development of the Cerebellum.Frontiers in cellular neuroscience · 2018Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
SDF-1/CXCR4 signalling plays an important role in neuronal cell migration and brain development. However, the impact of CXCR4 deficiency in the postnatal mouse brain is still poorly understood. Here, we demonstrate the importance of CXCR4 on cerebellar development and motor behaviour by conditional inactivation of Cxcr4 in the central nervous system. We found CXCR4 plays a key role in cerebellar development. Its loss leads to defects in Purkinje cell dentritogenesis and axonal projection in vivo but not in cell culture. Transcriptome analysis revealed the most significantly affected pathways in the Cxcr4 deficient developing cerebellum are involved in extra cellular matrix receptor interactions and focal adhesion. Consistent with functional impairment of the cerebellum, Cxcr4 knockout mice have poor coordination and balance performance in skilled motor tests. Together, these results suggest ectopic the migration of granule cells impairs development of Purkinje cells, causes gross cerebellar anatomical disruption and leads to behavioural motor defects in Cxcr4 null mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.