Evidence map›Paper›PMID 24516494›Full record

ReviewJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2013

Pharmacokinetic drug-drug interaction and their implication in clinical management.

Caterina Palleria, Antonello Di Paolo, Chiara Giofrè, Chiara Caglioti, Giacomo Leuzzi, Antonio Siniscalchi, Giovambattista De Sarro, Luca Gallelli

Abstract readReview
In one paragraph

Review in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Prevalence of drug interactions in hospitalised elderly patients: a systematic review.European journal of hospital pharmacy : science and practice · 2021
    Pooled it
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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caterina PalleriaDepartment of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
Antonello Di PaoloDepartment of Clinical and Experimental Medicine, Division of Pharmacology, University of Pisa, Italy.
Chiara GiofrèDepartment of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
Chiara CagliotiDepartment of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
Giacomo LeuzziAzienda Sanitaria Provinciale Catanzaro, Department of Primary Care, Italy.
Antonio SiniscalchiDepartment of Neurology, Cosenza Hospital, Italy.
Giovambattista De SarroDepartment of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
Luca GallelliDepartment of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.

Indexed as

Absorptionadverse drug reactiondistributiondrug-drug interactionsexcretionmetabolismpoly-therapy

Identifiers

PMID24516494
PMCPMC3897029

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.