ArticleJournal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent2014
Differential Anterior Cingulate Activity during Response Inhibition in Depressed Adolescents with Bipolar and Unipolar Major Depressive Disorder.
Article in Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 7 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Executive functioning in adolescents with internalizing disorders: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.Psychological medicine · 2025Pooled it
- Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications.Neuroscience and biobehavioral reviews · 2023Pooled it
- Differentiation between bipolar disorder and major depressive disorder in adolescents: from clinical to biological biomarkers.Frontiers in human neuroscience · 2023Pooled it
- Actigraphically measured psychomotor slowing in depression: systematic review and meta-analysis.Psychological medicine · 2022Pooled it
- Differentiating bipolar disorder from unipolar depression in youth: A systematic literature review of neuroimaging research studies.Psychiatry research. Neuroimaging · 2021Pooled it
- Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth.JAMA psychiatry · 2015Pooled it
- Error monitoring and response inhibition in adolescents with bipolar disorders: An ERP study.Cognitive, affective & behavioral neuroscience · 2025Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults.The international journal of neuropsychopharmacology · 2024Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Distinguishing Bipolar Depression from Unipolar Depression in Youth: Preliminary Findings.Journal of child and adolescent psychopharmacology · 2017Article
- Amplitude of low-frequency fluctuations in first-episode, drug-naïve depressive patients: A 5-year retrospective study.PloS one · 2017Article
- The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression.Journal of psychiatric research · 2016Article
- The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder.PLoS genetics · 2016Article
- Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder.Translational psychiatry · 2016Article
- Distinguishing bipolar disorder from other psychiatric disorders in children.Current psychiatry reports · 2014Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveCognitive control deficits are commonly seen in Depression of Bipolar Disorder (BDd) and Unipolar Major Depressive Disorder (UDd). Because failure to differentiate BDd from UDd has significant clinical consequences we aimed to identify differential patterns of neural activity in BDd versus UDd underlying response inhibition and motor control in adolescents.
methodsFunctional MRI was used to compare 12 BDd adolescents (mean age= 15.5±1.2) with age- and sex-matched ten UDd and ten healthy control (HC) adolescents during the performance of well-validated Go/NoGo task. NoGo response inhibition versus Go motor control blocks was used in whole-brain analysis and results were corrected for multiple comparisons.
resultsThere were no significant behavioral or neuroimaging findings between adolescents with BDd and UDd. However, both groups relative to HC showed significantly higher left superior temporal and left caudate activity during the NoGo condition. Moreover, left anterior cingulate (ACC) activity relative to HC was significantly higher only in BDd - not UDd - adolescents during the NoGo condition, and left caudate activity was higher only in UDd - not BDd - adolescents during the Go condition. In addition, several neural regions including dorsolateral prefrontal (DLPFC) were positively correlated with increased reaction time in UDd - not BDd - adolescents.
conclusionsDespite some similarities, neural correlates of depression are different in BDd and UDd relative to HC, and greater recruitment of ACC resources during response inhibition can help distinguish BDd.
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24516473PMC3917665What OpenQuestion holds
Registered trials
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