Evidence map›Paper›PMID 24516412›Full record

ArticleDementia and geriatric cognitive disorders extra2013

CERAD Neuropsychological Total Scores Reflect Cortical Thinning in Prodromal Alzheimer's Disease.

T Paajanen, T Hänninen, A Aitken, M Hallikainen, E Westman, L-O Wahlund, T Sobow, P Mecocci, M Tsolaki, B Vellas and 6 more

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In one paragraph

Article in Dementia and geriatric cognitive disorders extra, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

T PaajanenCognition and Work Team, Finnish Institute of Occupational Health, Helsinki, Kuopio, Finland ; Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
T HänninenDepartment of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
A AitkenInstitute of Psychiatry and NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, King's College London ; Department of Medical Engineering and Physics, King's College Hospital NHS Foundation Trust, London, UK.
M HallikainenDepartment of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
E WestmanDepartment of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
L-O WahlundDepartment of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
T SobowDepartment of Medical Psychology, Medical University of Lodz, Lodz, Poland.
P MecocciInstitute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
M Tsolaki3rd University Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
B VellasToulouse Gérontopôle University Hospital, Université Paul Sabatier, INSERM U 558, Toulouse, France.
S MuehlboeckInstitute of Psychiatry and NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, King's College London ; Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
C SpengerDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
S LovestoneInstitute of Psychiatry and NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, King's College London ; MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, UK.
A SimmonsInstitute of Psychiatry and NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust, King's College London ; MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London, UK.
H SoininenDepartment of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
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Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSensitive cognitive global scores are beneficial in screening and monitoring for prodromal Alzheimer's disease (AD). Early cortical changes provide a novel opportunity for validating established cognitive total scores against the biological disease markers.

methodsWe examined how two different total scores of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery and the Mini-Mental State Examination (MMSE) are associated with cortical thickness (CTH) in mild cognitive impairment (MCI) and prodromal AD. Cognitive and magnetic resonance imaging (MRI) data of 22 progressive MCI, 78 stable MCI, and 98 control subjects, and MRI data of 103 AD patients of the prospective multicenter study were analyzed.

resultsCERAD total scores correlated with mean CTH more strongly (r = 0.34-0.38, p < 0.001) than did MMSE (r = 0.19, p = 0.01). Of those vertex clusters that showed thinning in progressive MCI, 60-75% related to the CERAD total scores and 3% to the MMSE.

conclusionCERAD total scores are sensitive to the CTH signature of prodromal AD, which supports their biological validity in detecting early disease-related cognitive changes.

Indexed as

AddNeuroMed studyAlzheimer's diseaseCognitionCortical thicknessMagnetic resonance imagingMemoryMild cognitive impairmentNeuropsychology

Identifiers

PMID24516412
PMCPMC3919432

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.