Evidence map›Paper›PMID 24516351›Full record

ArticleInternational journal of medical sciences2014

Role of overexpression of MACC1 and/or FAK in predicting prognosis of hepatocellular carcinoma after liver transplantation.

Sheng Gao, Bing-Yi Lin, Zhe Yang, Zhi-Yun Zheng, Zhi-Kun Liu, Li-Ming Wu, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. MACC1 overexpression and survival in solid tumors: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sheng Gao1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
Bing-Yi Lin1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
Zhe Yang1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhi-Yun Zheng1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
Zhi-Kun Liu1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
Li-Ming Wu1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hai-Yang Xie1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lin Zhou1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shu-Sen Zheng1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastasis-associated in colon cancer-1 (MACC1) acts as a promoter of tumor metastasis; however, the predictive value of MACC1 for hepatocellular carcinoma (HCC) after liver transplantation (LT) remains unclear.

methodsWe examined the expression of MACC1 and its target genes MET and FAK by quantitative PCR in 160 patients with HCC that was undergone LT.

resultsThe patients with MACC1(high) or FAK(high) in HCCs showed a significantly shorter overall survival and higher cumulative recurrence rates after liver transplantation (LT), compared with MACC1(low) or FAK(low) group. Multivariate analysis indicated that MACC1 alone or combination of MACC1/FAK was an independent prognostic factor for overall survival and cumulative recurrence.

conclusionsMACC1 or combination of MACC1/FAK could serve as a novel biomarker in predicting the prognosis of HCC after LT.

Indexed as

AdultAgedBiomarkers, TumorCarcinoma, HepatocellularFemaleFocal Adhesion Kinase 1Gene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm MetastasisPrognosisProto-Oncogene Proteins c-metBiomarkers, TumorFocal Adhesion Kinase 1MACC1 protein, humanMET protein, humanProto-Oncogene Proteins c-metPTK2 protein, humanTrans-ActivatorsTranscription Factorshepatocellular carcinomaliver transplantationmetastasismetastasis-associated in colon cancer-1prognosis

Identifiers

PMID24516351
PMCPMC3917116
OpenAlexW2062683938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.