ArticleProceedings of the National Academy of Sciences of the United States of America2014
Morphogenesis at criticality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Time-dependent bistability leads to critical slowing down during floral transition in Arabidopsis.Nature communications · 2026Article
- Bayesian Decision-Making Shapes Phenotypic Landscapes from Differentiation to Cancer.Entropy (Basel, Switzerland) · 2026Article
- Cell jamming transitions can affect regulatory protein gradients and prime evolutionary divergence.Journal of the Royal Society, Interface · 2025Article
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- Why collective behaviours self-organize to criticality: a primer on information-theoretic and thermodynamic utility measures.Royal Society open science · 2025Article
- Quantifying the genetic origins of body plan scaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stochastic morphological swings inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Deriving a genetic regulatory network from an optimization principle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- Selectively advantageous instability in biotic and pre-biotic systems and implications for evolution and aging.Frontiers in aging · 2024Review
- Scale invariance in early embryonic development.ArXiv · 2023Article
- Quantitative insights in tissue growth and morphogenesis with optogenetics.Physical biology · 2023Review
- Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Unsupervised learning of aging principles from longitudinal data.Nature communications · 2022Article
- Latent space of a small genetic network: Geometry of dynamics and information.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sculpting tissues by phase transitions.Nature communications · 2022Review
- Microenvironment-mediated cancer dormancy: Insights from metastability theory.Proceedings of the National Academy of Sciences of the United States of America · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Spatial patterns in the early fruit fly embryo emerge from a network of interactions among transcription factors, the gap genes, driven by maternal inputs. Such networks can exhibit many qualitatively different behaviors, separated by critical surfaces. At criticality, we should observe strong correlations in the fluctuations of different genes around their mean expression levels, a slowing of the dynamics along some but not all directions in the space of possible expression levels, correlations of expression fluctuations over long distances in the embryo, and departures from a Gaussian distribution of these fluctuations. Analysis of recent experiments on the gap gene network shows that all these signatures are observed, and that the different signatures are related in ways predicted by theory. Although there might be other explanations for these individual phenomena, the confluence of evidence suggests that this genetic network is tuned to criticality.
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