ArticleProceedings of the National Academy of Sciences of the United States of America2014
The predictability of molecular evolution during functional innovation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed.
- Article
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- Mutualism breakdown underpins evolutionary rescue in an obligate cross-feeding bacterial consortium.Nature communications · 2025Article
- Evolution recovers the fitness of Acinetobacter baylyi strains with large deletions through mutations in deletion-specific targets and global post-transcriptional regulators.PLoS genetics · 2024Article
- Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria.Nature communications · 2024Article
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- How selection shapes the short- and long-term dynamics of molecular evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate.Molecular biology and evolution · 2023Article
- Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast.Nature ecology & evolution · 2022Article
- Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution.Nature ecology & evolution · 2022Article
- Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification.Molecular biology and evolution · 2022Article
- Non-genetic and genetic rewiring underlie adaptation to hypomorphic alleles of an essential gene.The EMBO journal · 2021Article
- The cost of evolved constitutiveEcology and evolution · 2021Article
- Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution.Science advances · 2021Article
- Review
- Genomic and phenotypic evolution ofeLife · 2020Article
- Evolutionary Repair Experiments as a Window to the Molecular Diversity of Life.Current biology : CB · 2020Review
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4 authors.
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Abstract
Determining the molecular changes that give rise to functional innovations is a major unresolved problem in biology. The paucity of examples has served as a significant hindrance in furthering our understanding of this process. Here we used experimental evolution with the bacterium Escherichia coli to quantify the molecular changes underlying functional innovation in 68 independent instances ranging over 22 different metabolic functions. Using whole-genome sequencing, we show that the relative contribution of regulatory and structural mutations depends on the cellular context of the metabolic function. In addition, we find that regulatory mutations affect genes that act in pathways relevant to the novel function, whereas structural mutations affect genes that act in unrelated pathways. Finally, we use population genetic modeling to show that the relative contributions of regulatory and structural mutations during functional innovation may be affected by population size. These results provide a predictive framework for the molecular basis of evolutionary innovation, which is essential for anticipating future evolutionary trajectories in the face of rapid environmental change.
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