ArticleProceedings of the National Academy of Sciences of the United States of America2014
Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- The RNA- and DNA-Binding Protein Y-Box Binding Protein 1 (YB-1) Regulates iNKT Cell Development.European journal of immunology · 2026Article
- The role of Raptor in lymphocytes differentiation and function.Frontiers in immunology · 2023Review
- PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis.Nature cell biology · 2022Article
- NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.Cell reports · 2022Article
- Effects of TNF-α deletion on iNKT cell development, activation, and maturation in the steady-state and chronic alcohol-consuming mice.Journal of leukocyte biology · 2022Article
- iNKT subsets differ in their developmental and functional requirements on Foxo1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Insulin-mediated immune dysfunction in the development of preeclampsia.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Role of TSC1 in physiology and diseases.Molecular and cellular biochemistry · 2021Review
- Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.Nature communications · 2021Article
- Mitochondrial metabolism is essential for invariant natural killer T cell development and function.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment.Frontiers in immunology · 2021Review
- Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.Frontiers in immunology · 2021Article
- Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.European journal of immunology · 2020Article
- Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells.The Journal of clinical investigation · 2020Article
- Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.The Journal of experimental medicine · 2020Article
- mTOR signaling at the crossroads of environmental signals and T-cell fate decisions.Immunological reviews · 2020Review
- Differential Control ofFrontiers in immunology · 2019Article
- Akt2 Regulates the Differentiation and Function of NKT17 Cells via FoxO-1-ICOS Axis.Frontiers in immunology · 2018Article
- The Role of Autophagy in iNKT Cell Development.Frontiers in immunology · 2018Review
- MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.Autophagy · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The mechanisms that control invariant natural killer T (iNKT)-cell development and function are still poorly understood. The mechanistic or mammalian target of rapamycin (mTOR) integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival. We report here that ablation of mTOR complex 1 (mTORC1) signaling by conditionally deleting Raptor causes severe defects in iNKT-cell development at early stages, leading to drastic reductions in iNKT-cell numbers in the thymus and periphery. In addition, loss of Raptor impairs iNKT-cell proliferation and production of cytokines upon α-galactosylceramide stimulation in vitro and in vivo, and inhibits liver inflammation in an iNKT cell-mediated hepatitis model. Furthermore, Raptor deficiency and rapamycin treatment lead to aberrant intracellular localization and functional impairment of promyelocytic leukemia zinc-finger, a transcription factor critical for iNKT-cell development and effector programs. Our findings define an essential role of mTORC1 to direct iNKT-cell lineage development and effector function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.