ArticleProceedings of the National Academy of Sciences of the United States of America2014
PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- A reciprocal inhibition model of alternations between under-/overemotional modulatory states in patients with PTSD.Molecular psychiatry · 2021Pooled it
- Meta-Analysis of Associations Between Hypothalamic-Pituitary-Adrenal Axis Genes and Risk of Posttraumatic Stress Disorder.Journal of traumatic stress · 2020Pooled it
- Role of social cognition in post-traumatic stress disorder: A review and meta-analysis.Genes, brain, and behavior · 2019Pooled it
- Association of Posttraumatic Stress Disorder With rs2267735 in the ADCYAP1R1 Gene: A Meta-Analysis.Journal of traumatic stress · 2017Pooled it
- Hormonal mechanisms of women's risk in the face of traumatic stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Prevalence and associated factors of migraine among female college students with premenstrual syndrome.Scientific reports · 2025Article
- Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models.Molecular psychiatry · 2025Review
- Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development.Cureus · 2025Review
- Cellular mechanisms underlying pituitary adenylate cyclase activating polypeptide-stimulated secretion in the adrenal medulla.Biochemical Society transactions · 2024Review
- Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior.Cell reports · 2024Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- A PACAP-activated network for secretion requires coordination of CaMolecular biology of the cell · 2024Article
- Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders.Molecular biology reports · 2024Review
- Pituitary adenylyl cyclase-activating polypeptide modulates the stress response: the involvement of different brain areas and microglia.Frontiers in psychiatry · 2024Review
- Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder.European journal of psychotraumatology · 2024Article
- Neural correlates of PTSD in women with childhood sexual abuse with and without PTSD and response to paroxetine treatment: A placebo-controlled, double-blind trial.Journal of affective disorders reports · 2023Article
- The functional heterogeneity of PACAP: Stress, learning, and pathology.Neurobiology of learning and memory · 2023Review
19 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 1 country.
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Abstract
We have recently found higher circulating levels of pituitary adenylate cyclase-activating polypeptide (PACAP) associated with posttraumatic stress disorder (PTSD) symptoms in a highly traumatized cohort of women but not men. Furthermore, a single nucleotide polymorphism in the PACAP receptor gene ADCYAP1R1, adenylate cyclase activating polypeptide 1 receptor type 1, was associated with individual differences in PTSD symptoms and psychophysiological markers of fear and anxiety. The current study outlines an investigation of individual differences in brain function associated with ADCYAP1R1 genotype. Forty-nine women who had experienced moderate to high levels of lifetime trauma participated in a functional MRI task involving passive viewing of threatening and neutral face stimuli. Analyses focused on the amygdala and hippocampus, regions that play central roles in the pathophysiology of PTSD and are known to have high densities of PACAP receptors. The risk genotype was associated with increased reactivity of the amygdala and hippocampus to threat stimuli and decreased functional connectivity between the amygdala and hippocampus. The findings indicate that the PACAP system modulates medial temporal lobe function in humans. Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in PTSD and other anxiety disorders.
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Registered trials
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