ArticleProceedings of the National Academy of Sciences of the United States of America2014
Parallel pathways convey olfactory information with opposite polarities in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 51 citations in OpenAlex.
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- Organization of the parallel antennal-lobe tracts in the moth.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Review
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- A new player in circadian networks: Role of electrical synapses in regulating functions of the circadian clock.Frontiers in physiology · 2022Review
- A Sexually Dimorphic Olfactory Neuron Mediates Fixed Action Transition during Courtship Ritual inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila.Nature communications · 2021Article
- Gap Junctions Between Striatal D1 Neurons and Cholinergic Interneurons.Frontiers in cellular neuroscience · 2021Article
- Internal state configures olfactory behavior and early sensory processing inScience advances · 2021Article
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- Scaling the interactive effects of attractive and repellent odours for insect search behaviour.Scientific reports · 2019Article
- Neurogenetic dissection of theeLife · 2019Article
- Mechanosensory circuits coordinate two opposing motor actions inScience advances · 2019Article
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- Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation ineLife · 2018Article
- Gap Junctions in the Nervous System: Probing Functional Connections Using New Imaging Approaches.Frontiers in cellular neuroscience · 2018Review
- Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila.Nature communications · 2017Article
- A Population of Projection Neurons that Inhibits the Lateral Horn but Excites the Antennal Lobe through Chemical Synapses inFrontiers in neural circuits · 2017Article
- The good, the bad, and the hungry: how the central brain codes odor valence to facilitate food approach in Drosophila.Current opinion in neurobiology · 2016Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In insects, olfactory information received by peripheral olfactory receptor neurons (ORNs) is conveyed from the antennal lobes (ALs) to higher brain regions by olfactory projection neurons (PNs). Despite the knowledge that multiple types of PNs exist, little is known about how these different neuronal pathways work cooperatively. Here we studied the Drosophila GABAergic mediolateral antennocerebral tract PNs (mlPNs), which link ipsilateral AL and lateral horn (LH), in comparison with the cholinergic medial tract PNs (mPNs). We examined the connectivity of mlPNs in ALs and found that most mlPNs received inputs from both ORNs and mPNs and participated in AL network function by forming gap junctions with other AL neurons. Meanwhile, mlPNs might innervate LH neurons downstream of mPNs, exerting a feedforward inhibition. Using dual-color calcium imaging, which enables a simultaneous monitoring of neural activities in two groups of PNs, we found that mlPNs exhibited robust odor responses overlapping with, but broader than, those of mPNs. Moreover, preferentially down-regulation of GABA in most mlPNs caused abnormal courtship and aggressive behaviors in male flies. These findings demonstrate that in Drosophila, olfactory information in opposite polarities are carried coordinately by two parallel and interacted pathways, which could be essential for appropriate behaviors.
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