Evidence map›Paper›PMID 24516105›Full record

ArticleHypertension (Dallas, Tex. : 1979)2014

Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.

Karla K V Haack, Noah J Marcus, Rodrigo Del Rio, Irving H Zucker, Harold D Schultz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Karla K V HaackDepartment of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198. hschultz@unmc.edu.
Noah J Marcus
Rodrigo Del Rio
Irving H Zucker
Harold D Schultz
University of Nebraska Medical Center · US

Funding

The Role of Excitatory Input into the PVN on Increased Sympathetic Drive in HeartP01HL062222 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHULTZ, HAROLD D · 1999 to 2019
$32.2M
Sympathetic Control in Heart Failure: A Role of StatinsR01HL038690 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZUCKER, IRVING H · 1987 to 2010
$2.2M
CARDIOPULMONARY REFLEXES IN HEART FAILURER37HL038690 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZUCKER, IRVING H · 1992 to 2001
$517k
Peripheral chemoreflex hypersensitivity and periodic breathing in heart failureF32HL108592 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MARCUS, NOAH JUSTIN · 2012 to 2014
$163k
Central GRK5 modulation of Angiotensin II receptor expression in heart failureF32HL116172 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HAACK, KARLA · 2012 to 2013
$106k
NHLBI NIH HHS F32 HL108592NHLBI NIH HHS F32 HL116172NHLBI NIH HHS HL038690NHLBI NIH HHS P01 HL062222NHLBI NIH HHS P01-HL62222NHLBI NIH HHS R01 HL038690NHLBI NIH HHS R37 HL038690
6 · The paper itself

Abstract

Cheyne-Stokes respiration and cardiac arrhythmias are associated with increased morbidity and mortality in patients with chronic heart failure (CHF). Enhanced carotid body chemoreflex (CBC) sensitivity is associated with these abnormalities in CHF. Reduced carotid body (CB) nitric oxide and nitric oxide synthase (NOS) levels play an important role in the enhanced CBC. In other disease models, Simvastatin (statin) treatment increases endothelial NOS, in part, by increasing Krüppel-like Factor 2 expression. We hypothesized that statin treatment would ameliorate enhanced CBC sensitivity as well as increased respiratory variability, apnea/hypopnea index, and arrhythmia index, in a rodent model of CHF. Resting breathing pattern, cardiac rhythm, and the ventilatory and CB chemoreceptor afferent responses to hypoxia were assessed in rats with CHF induced by coronary ligation. CHF was associated with enhanced ventilatory and CB afferent responses to hypoxia as well as increased respiratory variability, apnea/hypopnea index, and arrhythmia index. Statin treatment prevented the increases in CBC sensitivity and the concomitant increases in respiratory variability, apnea/hypopnea index, and arrhythmia index. Krüppel-like Factor 2 and endothelial NOS protein were decreased in the CB and nucleus tractus solitarii of CHF animals, and statin treatment increased the expression of these proteins. Our findings demonstrate that the increased CBC sensitivity, respiratory instability, and cardiac arrhythmias observed in CHF are ameliorated by statin treatment and suggest that statins may be an effective treatment for Cheyne-Stokes respiration and arrhythmias in patient populations with high chemoreflex sensitivity.

Indexed as

AnimalsArrhythmias, CardiacCarotid BodyChronic DiseaseDisease Models, AnimalHeart FailureHydroxymethylglutaryl-CoA Reductase InhibitorsKruppel-Like Transcription FactorsMaleNitric OxideNitric Oxide Synthase Type IIIRatsRats, Sprague-DawleyReceptor, Angiotensin, Type 1RespirationSimvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsKlf2 protein, ratKruppel-Like Transcription FactorsNitric OxideNitric Oxide Synthase Type IIIReceptor, Angiotensin, Type 1Simvastatincarotid bodyCheyne–Stokes Respirationsimvastatinsystolic heart failure

Identifiers

PMID24516105
PMCPMC3993007
OpenAlexW2138369266

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.