Evidence map›Paper›PMID 24515519›Full record

ArticlePediatrics2014

Ultrasound as a screening test for genitourinary anomalies in children with UTI.

Caleb P Nelson, Emilie K Johnson, Tanya Logvinenko, Jeanne S Chow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
26.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
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  9. Article
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  13. Do infants in the neonatal intensive care unit diagnosed with urinary tract infection need a routine voiding cystourethrogram?The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Acute pyelonephritis in children.Pediatric nephrology (Berlin, Germany) · 2016
    Review
  20. Approach to Pediatric Patients with UTI in the PICU.Journal of pediatric intensive care · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Caleb P NelsonDepartment of Urology;
Emilie K Johnson
Tanya Logvinenko
Jeanne S Chow
Center for Clinical Research (United States) · USHarvard University · US

Funding

Clinical Outcomes for Siblings of Children with Vesico-Ureteral RefluxK23DK088943 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI NELSON, CALEB PENNELL · 2010 to 2014
$892k
Expanding training in comparative effectiveness for child health researchersT32HS019485 · AHRQ · BOSTON CHILDREN'S HOSPITAL · PI FINKELSTEIN, JONATHAN A · 2010 to 2010
$825k
AHRQ HHS T32 HS019485AHRQ HHS T32 HS19485NIDDK NIH HHS K23 DK088943NIDDK NIH HHS K23-DK088943
6 · The paper itself

Abstract

backgroundThe 2011 American Academy of Pediatrics guidelines state that renal and bladder ultrasound (RBUS) should be performed after initial febrile urinary tract infection (UTI) in a young child, with voiding cystourethrogram (VCUG) performed only if RBUS shows abnormalities. We sought to determine test characteristics and predictive values of RBUS for VCUG findings in this setting.

methodsWe analyzed 3995 clinical encounters from January 1, 2006 to December 31, 2010 during which VCUG and RBUS were performed for history of UTI. Patients who had previous postnatal genitourinary imaging or history of prenatal hydronephrosis were excluded. Sensitivity, specificity, and predictive values of RBUS for VCUG abnormalities were determined.

resultsWe identified 2259 patients age <60 months who had UTI as the indication for imaging. RBUS was reported as "normal" in 75%. On VCUG, any vesicoureteral reflux (VUR) was identified in 41.7%, VUR grade >II in 20.9%, and VUR grade >III in 2.8%. Sensitivity of RBUS for any abnormal findings on VCUG ranged from 5% (specificity: 97%) to 28% (specificity: 77%). Sensitivity for VUR grade >III ranged from 18% (specificity: 97%) to 55% (specificity: 77%). Among the 1203 children aged 2 to 24 months imaged after a first febrile UTI, positive predictive value of RBUS was 37% to 47% for VUR grade >II (13% to 24% for VUR grade >III); negative predictive value was 72% to 74% for VUR grade >II (95% to 96% for VUR grade >III).

conclusionsRBUS is a poor screening test for genitourinary abnormalities. RBUS and VCUG should be considered complementary as they provide important, but different, information.

Indexed as

Child, PreschoolFemaleHumansInfantMaleMass ScreeningUltrasonographyUrinary Tract InfectionsUrogenital Abnormalitiesimagingpediatricsurinary tract infectionvesicoureteral reflux

Identifiers

PMID24515519
PMCPMC3934332
OpenAlexW2160967166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.