ArticleG3 (Bethesda, Md.)2014
Horizontal transfer and gene conversion as an important driving force in shaping the landscape of mitochondrial introns.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Mitogenomics inMicrobial genomics · 2026Article
- Characterization and phylogenetic analysis of the complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2026Article
- An Alternative Self-Splicing Intron Lifecycle Revealed by Dynamic Intron Turnover in Epichloë Endophyte Mitochondrial Genomes.Molecular biology and evolution · 2025Article
- Intermolecular Gene Conversion for the Equalization of Genome Copies in the Polyploid HaloarchaeonGenes · 2024Article
- Insights into Fungal Mitochondrial Genomes and Inheritance Based on Current Findings from Yeast-like Fungi.Journal of fungi (Basel, Switzerland) · 2024Review
- Mitochondrial Genome Diversity across the Subphylum Saccharomycotina.bioRxiv : the preprint server for biology · 2023Article
- Functional annotation and comparative analysis of fourSaudi journal of biological sciences · 2023Article
- The mitogenomes ofFrontiers in microbiology · 2023Article
- Mitochondrial genome diversity across the subphylum Saccharomycotina.Frontiers in microbiology · 2023Article
- From Genome Variation to Molecular Mechanisms: What we Have Learned From Yeast Mitochondrial Genomes?Frontiers in microbiology · 2022Review
- Organellar Introns in Fungi, Algae, and Plants.Cells · 2021Review
- A functional bacteria-derived restriction modification system in the mitochondrion of a heterotrophic protist.PLoS biology · 2021Article
- Revealing the high variability on nonconserved core and mobile elements of Austropuccinia psidii and other rust mitochondrial genomes.PloS one · 2021Article
- Mitochondrial Genomics of Six Cacao Pathogens From the Basidiomycete FamilyFrontiers in microbiology · 2021Article
- Recent and Ongoing Horizontal Transfer of Mitochondrial Introns Between Two Fungal Tree Pathogens.Frontiers in microbiology · 2021Article
- The Mitogenomes ofFrontiers in microbiology · 2021Article
- Evolution of a Record-Setting AT-Rich Genome: Indel Mutation, Recombination, and Substitution Bias.Genome biology and evolution · 2020Article
- First characterization of the complete mitochondrial genome of fungal plant-pathogen Monilinia laxa which represents the mobile intron rich structure.Scientific reports · 2020Article
- Synthetic hybrids of six yeast species.Nature communications · 2020Article
- Mitochondrial genome and diverse inheritance patterns in Pleurotus pulmonarius.Journal of microbiology (Seoul, Korea) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group I introns are highly dynamic and mobile, featuring extensive presence-absence variation and widespread horizontal transfer. Group I introns can invade intron-lacking alleles via intron homing powered by their own encoded homing endonuclease gene (HEG) after horizontal transfer or via reverse splicing through an RNA intermediate. After successful invasion, the intron and HEG are subject to degeneration and sequential loss. It remains unclear whether these mechanisms can fully address the high dynamics and mobility of group I introns. Here, we found that HEGs undergo a fast gain-and-loss turnover comparable with introns in the yeast mitochondrial 21S-rRNA gene, which is unexpected, as the intron and HEG are generally believed to move together as a unit. We further observed extensively mosaic sequences in both the introns and HEGs, and evidence of gene conversion between HEG-containing and HEG-lacking introns. Our findings suggest horizontal transfer and gene conversion can accelerate HEG/intron degeneration and loss, or rescue and propagate HEG/introns, and ultimately result in high HEG/intron turnover rate. Given that up to 25% of the yeast mitochondrial genome is composed of introns and most mitochondrial introns are group I introns, horizontal transfer and gene conversion could have served as an important mechanism in introducing mitochondrial intron diversity, promoting intron mobility and consequently shaping mitochondrial genome architecture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.