ArticleCellular and molecular life sciences : CMLS2014
Recent advances in the biosynthesis of modified tetrapyrroles: the discovery of an alternative pathway for the formation of heme and heme d 1.
Article in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Biosensors for Detection of Labile Heme in Biological Samples.Biosensors · 2025Review
- BioIron: Origin, Chemical Properties, and Biological Functions.Advances in experimental medicine and biology · 2025Review
- Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials.Biomolecules · 2023Article
- Microbial Synthesis of HemeMolecules (Basel, Switzerland) · 2023Review
- Highlighting the Unique Roles of RadicalJournal of bacteriology · 2022Review
- A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.International journal of molecular sciences · 2022Review
- Article
- Transcriptional and Post-transcriptional Control of the Nitrate Respiration in Bacteria.Frontiers in molecular biosciences · 2021Review
- Aerobic Denitrification and Heterotrophic Sulfur Oxidation in the GenusFrontiers in microbiology · 2021Article
- Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection.The Journal of infectious diseases · 2019Article
- Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins.BMC microbiology · 2019Article
- Article
- 'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.Nature communications · 2017Article
- The Porphobilinogen Conundrum in Prebiotic Routes to Tetrapyrrole Macrocycles.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2017Article
- Alleviation of Nitrogen and Sulfur Deficiency and Enhancement of Photosynthesis inFrontiers in plant science · 2017Article
- Heme Synthesis and Acquisition in Bacterial Pathogens.Journal of molecular biology · 2016Review
- Conformational Dynamics, Ligand Binding and Effects of Mutations in NirE an S-Adenosyl-L-Methionine Dependent Methyltransferase.Scientific reports · 2016Article
- Determination of porphyrins in oral bacteria by liquid chromatography electrospray ionization tandem mass spectrometry.Analytical and bioanalytical chemistry · 2015Article
- HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria.Archives of biochemistry and biophysics · 2015Review
- Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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5 authors at 2 institutions in 1 country.
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Abstract
Hemes (a, b, c, and o) and heme d 1 belong to the group of modified tetrapyrroles, which also includes chlorophylls, cobalamins, coenzyme F430, and siroheme. These compounds are found throughout all domains of life and are involved in a variety of essential biological processes ranging from photosynthesis to methanogenesis. The biosynthesis of heme b has been well studied in many organisms, but in sulfate-reducing bacteria and archaea, the pathway has remained a mystery, as many of the enzymes involved in these characterized steps are absent. The heme pathway in most organisms proceeds from the cyclic precursor of all modified tetrapyrroles uroporphyrinogen III, to coproporphyrinogen III, which is followed by oxidation of the ring and finally iron insertion. Sulfate-reducing bacteria and some archaea lack the genetic information necessary to convert uroporphyrinogen III to heme along the "classical" route and instead use an "alternative" pathway. Biosynthesis of the isobacteriochlorin heme d 1, a cofactor of the dissimilatory nitrite reductase cytochrome cd 1, has also been a subject of much research, although the biosynthetic pathway and its intermediates have evaded discovery for quite some time. This review focuses on the recent advances in the understanding of these two pathways and their surprisingly close relationship via the unlikely intermediate siroheme, which is also a cofactor of sulfite and nitrite reductases in many organisms. The evolutionary questions raised by this discovery will also be discussed along with the potential regulation required by organisms with overlapping tetrapyrrole biosynthesis pathways.
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