ArticleGenetics2014
Mutation of a cuticular protein, BmorCPR2, alters larval body shape and adaptability in silkworm, Bombyx mori.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Cell and tissue mechanics in 3-D organ morphogenesis: Insights from Drosophila pupal retina development.Developmental biology · 2026Review
- A natural solution from caterpillar cuticles for flexible impact-resistant materials.Nature communications · 2026Article
- Article
- Partial deletion in the cuticular protein gene BmorCPR2 results in a body shape mutant in silkworm, Bombyx mori L. (Lepidoptera: Bombycidae).Journal of insect science (Online) · 2026Article
- Gene Expression and Structural Differences Underpinning Black and White Colouration in Spiders.Molecular ecology · 2026Article
- The cellular basis of locomotor evolution: insights from larval insects.Current opinion in behavioral sciences · 2026Article
- Transcriptomic landscape and chromatin accessibility uncover pivotal regulators driving programmed larval-larval molting in the domesticated silkworm.PLoS genetics · 2025Article
- The dual role of the RR-2 cuticular protein gene in development and acaricide susceptibility of Panonychus citri (Acari: Tetranychidae).Experimental & applied acarology · 2025Article
- A taste of one's own medicine:Frontiers in immunology · 2025Article
- Article
- Sprayable RNAi for silencing of important genes to manage red palm weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae).PloS one · 2024Article
- Article
- Ozone reduces lifespan and alters gene expression profiles in3 Biotech · 2022Article
- Article
- A Blueprint of Microstructures and Stage-Specific Transcriptome Dynamics of Cuticle Formation inInternational journal of molecular sciences · 2022Article
- Cuticle Protein LmACP19 Is Required for the Stability of Epidermal Cells in Wing Development and Morphogenesis ofInternational journal of molecular sciences · 2022Article
- Identification and temporal expression profiles of cuticular proteins in the endoparasitoid wasp, Microplitis mediator.Insect science · 2020Article
- Cuticular Structure Proteomics in the Pea AphidJournal of proteome research · 2020Article
- Comparative transcriptomic analysis and endocuticular protein gene expression of alate adults, workers and soldiers of the termite Reticulitermes aculabialis.BMC genomics · 2019Article
- RNA interference-mediated knockdown of 3, 4-dihydroxyphenylacetaldehyde synthase affects larval development and adult survival in the mosquito Aedes aegypti.Parasites & vectors · 2019Article
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15 authors.
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Abstract
Cuticular proteins (CPs) are crucial components of the insect cuticle. Although numerous genes encoding cuticular proteins have been identified in known insect genomes to date, their functions in maintaining insect body shape and adaptability remain largely unknown. In the current study, positional cloning led to the identification of a gene encoding an RR1-type cuticular protein, BmorCPR2, highly expressed in larval chitin-rich tissues and at the mulberry leaf-eating stages, which is responsible for the silkworm stony mutant. In the Dazao-stony strain, the BmorCPR2 allele is a deletion mutation with significantly lower expression, compared to the wild-type Dazao strain. Dysfunctional BmorCPR2 in the stony mutant lost chitin binding ability, leading to reduced chitin content in larval cuticle, limitation of cuticle extension, abatement of cuticle tensile properties, and aberrant ratio between internodes and intersegmental folds. These variations induce a significant decrease in cuticle capacity to hold the growing internal organs in the larval development process, resulting in whole-body stiffness, tightness, and hardness, bulging intersegmental folds, and serious defects in larval adaptability. To our knowledge, this is the first study to report the corresponding phenotype of stony in insects caused by mutation of RR1-type cuticular protein. Our findings collectively shed light on the specific role of cuticular proteins in maintaining normal larval body shape and will aid in the development of pest control strategies for the management of Lepidoptera.
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