ArticleMolecular psychiatry2015
Subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder.
Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium.Brain and behavior · 2022Pooled it
- The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder.Translational psychiatry · 2022Pooled it
- Altered cognitive response to serotonin challenge as a candidate endophenotype for obsessive-compulsive disorder.Psychopharmacology · 2016Trial
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.Communications biology · 2026Article
- Exploring connectivity and volume alterations in the Pulvinar's subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD).Psychological medicine · 2025Article
- Decision-making using the Iowa gambling test in unaffected first-degree relatives of obsessive-compulsive disorder: Comparison with healthy controls and patients with obsessive-compulsive disorder.Journal of neuropsychology · 2025Article
- Aberrant cortico-striatal white matter connectivity and associated subregional microstructure of the striatum in obsessive-compulsive disorder.Molecular psychiatry · 2022Article
- Functional Connectivity within the Frontal-Striatal Network Differentiates Checkers from Washers of Obsessive-Compulsive Disorder.Brain sciences · 2022Article
- An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.Human brain mapping · 2022Review
- Imaging Genetics in Epilepsy: Current Knowledge and New Perspectives.Frontiers in molecular neuroscience · 2022Review
- Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Abnormal brain functional network dynamics in obsessive-compulsive disorder patients and their unaffected first-degree relatives.Human brain mapping · 2021Article
- Smaller volume of posterior thalamic nuclei in patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2021Article
- Altered Resting-State Brain Activity in Schizophrenia and Obsessive-Compulsive Disorder Compared With Non-psychiatric Controls: Commonalities and Distinctions Across Disorders.Frontiers in psychiatry · 2021Article
- Caudate nuclei volume alterations and cognition and mood dysfunctions in adolescents with single ventricle heart disease.Journal of neuroscience research · 2020Article
- Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative.BMC psychiatry · 2020Article
- Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.Brain : a journal of neurology · 2020Article
- Basal ganglia volume and shape in anorexia nervosa.Appetite · 2020Article
- MR-based age-related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Endophentoypes, quantifiable traits lying on the causal chain between a clinical phenotype and etiology, can be used to accelerate genomic discovery in obsessive-compulsive disorder (OCD). Here we identify the neuroanatomic changes that are shared by 22 OCD adult and adolescent patients and 25 of their unaffected siblings who are at genetic risk for the disorder. Comparisons were made against 47 age and sex matched healthy controls. We defined the surface morphology of the striatum, globus pallidus and thalamus, and thickness of the cerebral cortex. Patients with OCD show significant surface expansion compared with healthy controls, following adjustment for multiple comparisons, in interconnected regions of the caudate, thalamus and right orbitofrontal cortex. Their unaffected siblings show similar, significant expansion, most marked in the ventromedial caudate bilaterally, the right pulvinar thalamic nucleus and the right orbitofrontal cortex. These regions define a network that has been consistently implicated in OCD. In addition, both patients with OCD and unaffected siblings showed similar increased thickness of the right precuneus, which receives rich input from the thalamic pulvinar nuclei and the left medial temporal cortex. Anatomic change within the orbitofrontostriatal and posterior brain circuitry thus emerges as a promising endophenotype for OCD.
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