Evidence map›Paper›PMID 24514567›Full record

ArticleMolecular psychiatry2014

A genome-wide association study of anorexia nervosa.

V Boraska, C S Franklin, J A B Floyd, L M Thornton, L M Huckins, L Southam, N W Rayner, I Tachmazidou, K L Klump, J Treasure and 167 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 7 pooled it
54.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 7 syntheses or guidelines pooled it, 332 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Utilising genomic association data for causal inference in anorexia nervosa.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  15. Article
  16. Polygenicity at the pathway level for anorexia nervosa.medRxiv : the preprint server for health sciences · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

177 authors at 20 institutions in 17 countries.

V Boraska1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] University of Split School of Medicine, Split, Croatia.
C S FranklinWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
J A B Floyd1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
L M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
L M HuckinsWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
L SouthamWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
N W Rayner1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford, UK [3] Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK.
I TachmazidouWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
K L KlumpDepartment of Psychology, Michigan State University, East Lansing, MI, USA.
J TreasureSection of Eating Disorders, Institute of Psychiatry, King's College London, London, UK.
C M LewisSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
U SchmidtSection of Eating Disorders, Institute of Psychiatry, King's College London, London, UK.
F TozziDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
K KiezebrinkHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.
J HebebrandDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
P Gorwood1] INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France [2] Sainte-Anne Hospital (CMME), University of Paris-Descartes, Paris, France.
R A H Adan1] Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands [2] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands.
M J H KasBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
A FavaroDepartment of Neurosciences, University of Padova, Padova, Italy.
P SantonastasoDepartment of Neurosciences, University of Padova, Padova, Italy.
F Fernández-Aranda1] Department of Psychiatry and CIBERON, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain [2] Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
M Gratacos1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
F RybakowskiDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
M Dmitrzak-WeglarzDepartment of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
J Kaprio1] Hjelt Institute, University of Helsinki, Helsinki, Finland [2] Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland [3] Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
A Keski-RahkonenHjelt Institute, University of Helsinki, Helsinki, Finland.
A Raevuori1] Hjelt Institute, University of Helsinki, Helsinki, Finland [2] Department of Adolescent Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
E F Van Furth1] Center for Eating Disorders Ursula, Leidschendam, The Netherlands [2] Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
M C T Slof-Op 't Landt1] Center for Eating Disorders Ursula, Leidschendam, The Netherlands [2] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
J I HudsonDepartment of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
T Reichborn-Kjennerud1] Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
G P S KnudsenDepartment of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
P Monteleone1] Department of Psychiatry, University of Naples SUN, Naples, Italy [2] Chair of Psychiatry, University of Salerno, Salerno, Italy.
A S Kaplan1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
A KarwautzEating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
H Hakonarson1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA [2] The Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
W H BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Y GuoThe Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
D LiThe Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
N J SchorkDepartment of Molecular and Experimental Medicine and The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA.
G Komaki1] Department of Psychosomatic Research, National Institute of Mental Health, NCNP, Tokyo, Japan [2] School of Health Sciences at Fukuoka, International University of Health and Welfare, Fukuoka, Japan.
T AndoDepartment of Psychosomatic Research, National Institute of Mental Health, NCNP, Tokyo, Japan.
H InokoDepartment of Molecular Life Sciences, Tokai University School of Medicine, Kanagawa, Japan.
T EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
K FischerEstonian Genome Center, University of Tartu, Tartu, Estonia.
K Männik1] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia [2] Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
A Metspalu1] Estonian Genome Center, University of Tartu, Tartu, Estonia [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
J H BakerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
R D ConeDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
J DackorDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J E DeSocioSeattle University College of Nursing, Seattle, WA, USA.
C E HilliardDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J K O'TooleKartini Clinic, Portland, OR, USA.
J PantelCentre de Psychiatrie et Neurosciences - Inserm U894, Paris, France.
J P SzatkiewiczDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
C TaicoDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S ZerwasDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S E TraceDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
O S P Davis1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Department of Genetics, Evolution and Environment, University College London, UCL Genetics Institute, London, UK.
S HelderSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
K BührenDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinics RWTH Aachen, Aachen, Germany.
R BurghardtDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Berlin, Germany.
M de Zwaan1] Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany [2] Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
K EgbertsDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Würzburg, Würzburg, Germany.
S Ehrlich1] Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany [2] Athinoula A. Martinos Center for Biomedical Imaging, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA.
B Herpertz-DahlmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinics RWTH Aachen, Aachen, Germany.
W HerzogDepartments of Psychosocial and Internal Medicine, Heidelberg University, Heidelberg, Germany.
H ImgartParklandklinik, Bad Wildungen, Germany.
A ScheragInstitute for Medical Informatics, Biometry and Epidemiology, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
S ScheragDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
S ZipfelDepartment of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, Tübingen, Germany.
C BoniINSERM U894, Centre of Psychiatry and Neuroscience, Paris, France.
N RamozINSERM U894, Centre of Psychiatry and Neuroscience, Paris, France.
A VersiniINSERM U894, Centre of Psychiatry and Neuroscience, Paris, France.
M K Brandys1] Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands [2] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands.
U N DannerAltrecht Eating Disorders Rintveld, Zeist, The Netherlands.
C de KovelDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
J HendriksBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
B P C KoelemanDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
R A Ophoff1] Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA [2] Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
E StrengmanDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
A A van Elburg1] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands [2] Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
A BrusonClinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
M ClementiClinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
D DegortesDepartment of Neurosciences, University of Padova, Padova, Italy.
M ForzanClinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
E TenconiDepartment of Neurosciences, University of Padova, Padova, Italy.
E Docampo1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
G Escaramís1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
S Jiménez-Murcia1] Department of Psychiatry and CIBERON, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain [2] Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
J LissowskaM. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
A RajewskiDepartment of Epidemiology, Institute of Occupational Medicine, Department of Epidemiology, Lodz, Poland.
N Szeszenia-DabrowskaDepartment of Epidemiology, Institute of Occupational Medicine, Department of Epidemiology, Lodz, Poland.
A SlopienDepartment of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
J HauserDepartment of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
L KarhunenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
I MeulenbeltMolecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
P E Slagboom1] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands.
A TortorellaDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
M MajDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
G DedoussisDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
D Dikeos1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
F GonidakisEating Disorders Unit, 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
K TziouvasDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
A TsitsikaAdolescent Health Unit (A.H.U.), 2nd Department of Pediatrics - Medical School, University of Athens 'P. & A. Kyriakou' Children's Hospital, Athens, Greece.
H PapezovaDepartment of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
L SlachtovaDepartment of Pediatrics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
D MartaskovaDepartment of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
J L Kennedy1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
R D Levitan1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Z Yilmaz1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
J HuemerEating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
D KoubekEating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
E MerlEating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
G WagnerEating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
P LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
G BreenSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
S Cohen-WoodsSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
A FarmerSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
P McGuffinSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
S Cichon1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
I GieglingKlinikum der Medizinischen Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
S Herms1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
D RujescuKlinikum der Medizinischen Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
S SchreiberInstitute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
H-E Wichmann1] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
C DinaCNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
R SladekMcGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
G GambaroDivision of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelly Hospitals, Catholic University, Rome, Italy.
N SoranzoWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
A JuliaUnitat de Recerca de Reumatologia (URR), Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
S MarsalUnitat de Recerca de Reumatologia (URR), Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
R Rabionet1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
V GaborieauGenetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
D M DickVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
A Palotie1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [3] The Program for Human and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
S Ripatti1] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Finnish Institute of Occupational Health, Helsinki, Finland.
E Widén1] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Finnish Institute of Occupational Health, Helsinki, Finland.
O A AndreassenNORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
T Espeseth1] NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
A Lundervold1] Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway [2] Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway [3] K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
I ReinvangDepartment of Psychology, University of Oslo, Oslo, Norway.
V M Steen1] Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
S Le Hellard1] Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
M MattingsdalNORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
I NtallaDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
V BenckoInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
L ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
V JanoutPalacky University, Olomouc, Czech Republic.
M NavratilovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
S Gallinger1] University Health Network, Toronto General Hospital, Toronto, ON, Canada [2] Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, ON, Canada.
D PintoDepartments of Psychiatry, and Genetics and Genomic Sciences, Seaver Autism Center, and the Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY, USA.
S W SchererThe Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
H AschauerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
L CarlbergDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
A SchosserDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
L AlfredssonThe Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
B DingThe Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
L KlareskogRheumatology Unit, Department of Medicine at the Karolinska University Hospital, Solna, Sweden.
L PadyukovRheumatology Unit, Department of Medicine at the Karolinska University Hospital, Solna, Sweden.
P Courtet1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
S Guillaume1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
I Jaussent1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
C FinanWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
G KalsiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
M RobertsSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
D W LoganWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
L PeltonenWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
G R S Ritchie1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge.
J C BarrettWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Wellcome Trust Case Control Consortium 3
X Estivill1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
A HinneyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
P F Sullivan1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
D A Collier1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Eli Lilly and Company, Erl Wood Manor, Windlesham, UK.
E ZegginiWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
C M Bulik1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wellcome Sanger Institute · GBUniversity of North Carolina at Chapel Hill · USKing's College London · GBMedical University of Vienna · ATUniversity of Padua · ITUniversity Medical Center Utrecht · NLUniversity of Helsinki · FICentre for Addiction and Mental Health · CACharles University · CZHospital del Mar Research Institute · ESUniversity of Tartu · EEAltrecht GGZ · NLChildren's Hospital of Philadelphia · USHarokopio University of Athens · GRInserm · FRInstitut de Psychiatrie et Neurosciences de Paris · FRKarolinska Institutet · SEOslo University Hospital · NOPoznan University of Medical Sciences · PLUniversity of Bergen · NO

Funding

Targeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MYERS, JEFFREY NICHOLAS · 2002 to 2012
$26.1M
UT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7M
ONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5M
UNC Clinical and Translational Science AwardUL1TR000083 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2012 to 2013
$11.6M
Colon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3M
UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Molecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3M
The Colon Cancer Family Registry: OntarioU24CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 2008 to 2011
$4.1M
High-density Genome-wide Association Study SchizophreniaR01MH078075 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OPHOFF, ROEL A · 2006 to 2009
$3.7M
Genetics of Anorexia NervosaR01MH066122 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAYE, WALTER H · 2002 to 2006
$3.1M
ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
Chief Scientist Office HSRU1Medical Research Council MR/J006742/1Medical Research Council MR/K500999/1NCATS NIH HHS UL1TR000083NCI NIH HHS 3P50CA093459NCI NIH HHS 5P50CA097007NCI NIH HHS 5R01CA133996NCI NIH HHS P50 CA093459NCI NIH HHS P50 CA097007NCI NIH HHS R01 CA133996NCI NIH HHS U01 CA074783NCI NIH HHS U24 CA074783NCI NIH HHS UM1 CA167551NCRR NIH HHS U54 RR0252204-01NIAAA NIH HHS AA-00145NIAAA NIH HHS AA-09203NIAAA NIH HHS AA-12502NIAAA NIH HHS AA15416NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502NICHD NIH HHS K12 HD001441NICHD NIH HHS K12HD001441NIEHS NIH HHS 5R01ES011740NIEHS NIH HHS R01 ES011740NIMH NIH HHS K01 MH100435NIMH NIH HHS MH066117NIMH NIH HHS MH066122NIMH NIH HHS MH066145NIMH NIH HHS MH066146NIMH NIH HHS MH066147NIMH NIH HHS MH066193NIMH NIH HHS MH0662NIMH NIH HHS MH066287NIMH NIH HHS MH066288NIMH NIH HHS MH066296NIMH NIH HHS R01 MH066117NIMH NIH HHS R01 MH066122NIMH NIH HHS R01 MH066145NIMH NIH HHS R01 MH066146NIMH NIH HHS R01 MH066147NIMH NIH HHS R01 MH066193NIMH NIH HHS R01 MH066287NIMH NIH HHS R01 MH066288NIMH NIH HHS R01 MH066296NIMH NIH HHS R01 MH078075NIMH NIH HHS T32 MH076694NINDS NIH HHS F32 NS010045Wellcome Trust 088827Wellcome Trust 090532Wellcome Trust WT088827/Z/09Wellcome Trust WT088984World Health Organization 001
6 · The paper itself

Abstract

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.

Indexed as

Anorexia NervosaAsian PeopleCalcineurinCarrier ProteinsCase-Control StudiesCullin ProteinsFemaleGenome-Wide Association StudyGuanine Nucleotide Exchange FactorsHumansJapanMaleMeta-Analysis as TopicNuclear ProteinsPolymorphism, Single NucleotideWhite PeopleCalcineurinCarrier ProteinsCUL3 protein, humanCullin ProteinsFAM124B protein, humanGuanine Nucleotide Exchange FactorsNuclear ProteinsPPP3CA protein, humanSPATA13 protein, human

Identifiers

PMID24514567
PMCPMC4325090
OpenAlexW2108356100

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