Evidence map›Paper›PMID 24514566›Full record

ArticleMolecular psychiatry2015

Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents.

S Desrivières, A Lourdusamy, C Tao, R Toro, T Jia, E Loth, L M Medina, A Kepa, A Fernandes, B Ruggeri and 28 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  20. Retrograde Amnesia - A Question of Disturbed Calcium Levels?Frontiers in cellular neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 18 institutions in 7 countries.

S Desrivières1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
A Lourdusamy1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
C TaoCenter for Computational Systems Biology, Fudan University, Shanghai, China.
R Toro1] Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France [2] CNRS URA 2182, Genes, synapses and cognition, Institut Pasteur, Paris, France.
T Jia1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
E Loth1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
L M Medina1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
A Kepa1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
A Fernandes1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
B Ruggeri1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
F M Carvalho1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
G CocksInstitute of Psychiatry, King's College, London, UK.
T Banaschewski1] Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany [2] Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
G J BarkerInstitute of Psychiatry, King's College, London, UK.ORCID 0000000252147421
A L W BokdeInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
C BüchelDepartment of Systems Neuroscience, Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
P J Conrod1] Institute of Psychiatry, King's College, London, UK [2] Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, QC, Canada.
H FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
A HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin, Berlin, Germany.
J GallinatDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin, Berlin, Germany.
H Garavan1] Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland [2] Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
P GowlandDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
R BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Berlin, Germany.
C LawrenceSchool of Psychology, University of Nottingham, Nottingham, UK.
K MannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.
M L P Martinot1] Institut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 'Imaging & Psychiatry', University Paris Sud, Orsay, France [2] AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France.
F NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
M LathropCentre National de Génotypage, Evry, France.
J-B PolineNeurospin, Commissariat àl'Energie Atomique et aux Energies Alternatives, Paris, France.
M RietschelDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.
P ThompsonImaging Genetics Center/Laborarory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA.
M Fauth-BühlerDepartment of Addictive Behaviour and Addiction Medicine, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
M N Smolka1] Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany [2] Department of Psychology, Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Z PausovaThe Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
T Paus1] School of Psychology, University of Nottingham, Nottingham, UK [2] Rotman Research Institute, University of Toronto, Toronto, ON, Canada [3] Montreal Neurological Institute, McGill University, Montreal, Canada.
J Feng1] Center for Computational Systems Biology, Fudan University, Shanghai, China [2] Department of Computer Science and Centre for Scientific Computing, Warwick University, Coventry, UK.
G Schumann1] Institute of Psychiatry, King's College, London, UK [2] MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
IMAGEN Consortium
King's College London · GBHeidelberg University · DECentral Institute of Mental Health · DECharité - Universitätsmedizin Berlin · DEFudan University · CNTrinity College Dublin · IECentre National de la Recherche Scientifique · FRCentre National de Recherche en Génomique Humaine · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRDélégation Paris 5 · FREppendorf (Germany) · DEImaging Center · USMontreal Neurological Institute and Hospital · CAPhysikalisch-Technische Bundesanstalt · DETechnische Universität Dresden · DEUniversity of Nottingham · GBUniversity of Toronto · CAUniversity of Vermont · US

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Medical Research Council G0901858Medical Research Council G93558
6 · The paper itself

Abstract

Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a large-scale association study in 1583 adolescents to identify genes affecting cortical thickness. Single-nucleotide polymorphisms (SNPs; n=54,837) within genes whose expression changed between stages of growth and differentiation of a human neural stem cell line were selected for association analyses with average cortical thickness. We identified a variant, rs7171755, associating with thinner cortex in the left hemisphere (P=1.12 × 10(-)(7)), particularly in the frontal and temporal lobes. Localized effects of this SNP on cortical thickness differently affected verbal and nonverbal intellectual abilities. The rs7171755 polymorphism acted in cis to affect expression in the human brain of the synaptic cell adhesion glycoprotein-encoding gene NPTN. We also found that cortical thickness and NPTN expression were on average higher in the right hemisphere, suggesting that asymmetric NPTN expression may render the left hemisphere more sensitive to the effects of NPTN mutations, accounting for the lateralized effect of rs7171755 found in our study. Altogether, our findings support a potential role for regional synaptic dysfunctions in forms of intellectual deficits.

Indexed as

AdolescentAnimalsBrainCells, CulturedCognitionFemaleGenetic Association StudiesHumansImage Processing, Computer-AssistedIntelligenceLinear ModelsMagnetic Resonance ImagingMaleMembrane GlycoproteinsMeta-Analysis as TopicMiceMembrane GlycoproteinsNPTN protein, human

Identifiers

PMID24514566
PMCPMC4051592
OpenAlexW2119421798

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.