Evidence map›Paper›PMID 24514565›Full record

ArticleMolecular psychiatry2014

Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus.

Sundari Chetty, Aaron R Friedman, Kereshmeh Taravosh-Lahn, Elizabeth D Kirby, Christian Mirescu, Fuzheng Guo, Danna Krupik, Andrea Nicholas, Anna Geraghty, Amrita Krishnamurthy and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it, 219 citations in OpenAlex.

  1. Pooled it
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  17. White and Gray Matter Abnormality in Burning Mouth Syndrome Evaluated with Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Article
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Sundari Chetty *Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
Aaron R Friedman *Department of Integrative Biology, University of California, Berkeley, Berkeley, CA.
Kereshmeh Taravosh-LahnDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA.
Elizabeth D KirbyHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
Christian MirescuDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA.
Fuzheng GuoInstitute for Pediatric Regenerative Medicine, University of California, Davis, School of Medicine and Shriners Hospital, Sacramento, CA.
Danna KrupikDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA.
Andrea NicholasDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA.
Anna GeraghtyDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA.
Amrita KrishnamurthyHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
Meng-Ko TsaiHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
David CovarrubiasDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.
Alana WongHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
Darlene FrancisHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
Robert M SapolskyDepartment of Biological Sciences, Stanford University, Stanford, CA.
Theo D PalmerDepartment of Neurosurgery, Stanford University, Stanford, CA.
David PleasureInstitute for Pediatric Regenerative Medicine, University of California, Davis, School of Medicine and Shriners Hospital, Sacramento, CA.
Daniela KauferHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA.
University of California, Berkeley · USStanford University · USUniversity of California, Davis · USBerkeley Public Health Division · US

Funding

Identification & Prevention of Developmental Myelin Misregulation in PTSDR01MH087495 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI KAUFER, DANIELA · 2009 to 2013
$2.5M
The Senescence of Adult Neuronal Precursors: Potential Glucocorticoid ModulationF32AG029733 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI MIRESCU, CHRISTIAN · 2007 to 2009
$159k
NIA NIH HHS 1F32AG029733-01A1NIA NIH HHS F32 AG029733NIMH NIH HHS R01 MH087495NIMH NIH HHS R01MH087495
6 · The paper itself

Abstract

Stress can exert long-lasting changes on the brain that contribute to vulnerability to mental illness, yet mechanisms underlying this long-term vulnerability are not well understood. We hypothesized that stress may alter the production of oligodendrocytes in the adult brain, providing a cellular and structural basis for stress-related disorders. We found that immobilization stress decreased neurogenesis and increased oligodendrogenesis in the dentate gyrus (DG) of the adult rat hippocampus and that injections of the rat glucocorticoid stress hormone corticosterone (cort) were sufficient to replicate this effect. The DG contains a unique population of multipotent neural stem cells (NSCs) that give rise to adult newborn neurons, but oligodendrogenic potential has not been demonstrated in vivo. We used a nestin-CreER/YFP transgenic mouse line for lineage tracing and found that cort induces oligodendrogenesis from nestin-expressing NSCs in vivo. Using hippocampal NSCs cultured in vitro, we further showed that exposure to cort induced a pro-oligodendrogenic transcriptional program and resulted in an increase in oligodendrogenesis and decrease in neurogenesis, which was prevented by genetic blockade of glucocorticoid receptor (GR). Together, these results suggest a novel model in which stress may alter hippocampal function by promoting oligodendrogenesis, thereby altering the cellular composition and white matter structure.

Indexed as

AnimalsCell DifferentiationCell ProliferationCells, CulturedCorticosteroneDisease Models, AnimalGlucocorticoidsHippocampusMaleMice, TransgenicNestinNeural Stem CellsNeuronsOligodendrogliaRats, Sprague-DawleyReceptors, GlucocorticoidCorticosteroneGlucocorticoidsNes protein, mouseNestinReceptors, GlucocorticoidRNA, Messenger

Identifiers

PMID24514565
PMCPMC4128957
OpenAlexW2029630254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.