Evidence map›Paper›PMID 24514041›Full record

ReviewCancer research2014

Light in and sound out: emerging translational strategies for photoacoustic imaging.

S Zackrisson, S M W Y van de Ven, S S Gambhir

Registry-linked trialAbstract readReview
In one paragraph

Review in Cancer research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03501823 (Photoacoustic Tomography of Normal and Abnormal Vasculature), which is not on this map. Cited by 198 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03501823 unknown statusnot on this mapstarted 2018, after this paper: background citation

Photoacoustic Tomography of Normal and Abnormal Vasculature: Feasibility of in Vivo Measurements.

TypeobservationalSponsorUniversity College, LondonRan2018 to 2018Enrolled27ConditionsCancer, Cardiovascular DiseasesArmsPhotoacoustic tomography
3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026
    Review
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  11. Article
  12. Article
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  15. Review
  16. Article
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  18. Review
  19. TowardsFundamental research · 2024
    Review
  20. Review

138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S Zackrisson *Departments of Radiology, Bioengineering, and Department of Materials Science & Engineering. Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
S M W Y van de Ven *Departments of Radiology, Bioengineering, and Department of Materials Science & Engineering. Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
S S GambhirDepartments of Radiology, Bioengineering, and Department of Materials Science & Engineering. Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Stanford Nanocharacterization LaboratoryU54CA119367 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2006 to 2010
$19.8M
Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2010 to 2014
$12.6M
New Tools for Prostate Cancer Detection and PrognosticationU01CA152737 · NCI · STANFORD UNIVERSITY · PI BROOKS, JAMES D., GAMBHIR, SANJIV S · 2010 to 2015
$2.8M
Improved Prostate Cancer Detection Using Combined Ultrasound and Photoacoustic ImR21CA178360 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2013 to 2014
$369k
NCI NIH HHS P50 CA114747NCI NIH HHS R21 CA178360NCI NIH HHS U01 CA152737NCI NIH HHS U54 CA119367NCI NIH HHS U54 CA151459
6 · The paper itself

Abstract

Photoacoustic imaging (PAI) has the potential for real-time molecular imaging at high resolution and deep inside the tissue, using nonionizing radiation and not necessarily depending on exogenous imaging agents, making this technique very promising for a range of clinical applications. The fact that PAI systems can be made portable and compatible with existing imaging technologies favors clinical translation even more. The breadth of clinical applications in which photoacoustics could play a valuable role include: noninvasive imaging of the breast, sentinel lymph nodes, skin, thyroid, eye, prostate (transrectal), and ovaries (transvaginal); minimally invasive endoscopic imaging of gastrointestinal tract, bladder, and circulating tumor cells (in vivo flow cytometry); and intraoperative imaging for assessment of tumor margins and (lymph node) metastases. In this review, we describe the basics of PAI and its recent advances in biomedical research, followed by a discussion of strategies for clinical translation of the technique.

Indexed as

Photoacoustic TechniquesAnimalsColoring AgentsContrast MediaDiagnostic Techniques, Obstetrical and GynecologicalDiagnostic Techniques, UrologicalEarly Detection of CancerFemaleHumansMaleMolecular ImagingNeoplasmsTranslational Research, BiomedicalColoring AgentsContrast Media

Identifiers

PMID24514041
PMCPMC3944207

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.