Trial reportThe American journal of gastroenterology2014
Lack of correlation between HRM metrics and symptoms during the manometric protocol.
Trial report in The American journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883175 (Evolution of the Chicago Classification), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Esophageal and Oropharyngeal Dysphagia: Clinical Recommendations From the United European Gastroenterology and European Society for Neurogastroenterology and Motility.United European gastroenterology journal · 2025Guideline
- Pooled it
- Rhythmic contraction but arrhythmic distension of esophageal peristaltic reflex in patients with dysphagia.PloS one · 2022Trial
- Esophageal Hypervigilance and Visceral Anxiety Are Contributors to Symptom Severity Among Patients Evaluated With High-Resolution Esophageal Manometry.The American journal of gastroenterology · 2020Trial
- Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia.World journal of gastroenterology · 2025Article
- Comparative Prevalence of Ineffective Esophageal Motility: Impact of Chicago v4.0 vs. v3.0 Criteria.Medicina (Kaunas, Lithuania) · 2024Article
- Why so Many Patients With Dysphagia Have Normal Esophageal Function Testing.Gastro hep advances · 2024Article
- The role of hypervigilance in chronic esophageal diseases: a scoping review.Translational gastroenterology and hepatology · 2024Article
- Empirical Dilation of Non-obstructive Dysphagia: Current Understanding and Future Directions.Digestive diseases and sciences · 2022Review
- Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics.Gastroenterology · 2022Review
- Differences in upper esophageal sphincter function and clinical characteristics among the three subtypes of Japanese patients with esophageal achalasia.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Article
- The semirecumbent position for high-resolution esophageal manometry. Results of a feasibility study.European journal of gastroenterology & hepatology · 2021Article
- Distension-contraction profile of peristalsis in patients with nutcracker esophagus.Neurogastroenterology and motility · 2021Article
- Diagnostic Yield of High-resolution Esophageal Manometry With Chicago Classification Version 3.0 in Thai Patients.Journal of neurogastroenterology and motility · 2021Article
- Chicago Classification Version 4.0 and Its Impact on Current Clinical Practice.Gastroenterology & hepatology · 2021Article
- Chicago classification version 4.0Neurogastroenterology and motility · 2021Review
- Abnormal Esophageal Distension Profiles in Patients With Functional Dysphagia: A Possible Mechanism of Dysphagia.Gastroenterology · 2021Article
- Management of Ineffective Esophageal Hypomotility.Frontiers in pharmacology · 2021Review
- High-Resolution Manometry-Observations After 15 Years of Personal Use-Has Advancement Reached a Plateau?Current gastroenterology reports · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesAlthough esophageal motor disorders are associated with chest pain and dysphagia, minimal data support a direct relationship between abnormal motor function and symptoms. This study investigated whether high-resolution manometry (HRM) metrics correlate with symptoms.
methodsConsecutive HRM patients without previous surgery were enrolled. HRM studies included 10 supine liquid, 5 upright liquid, 2 upright viscous, and 2 upright solid swallows. All patients evaluated their esophageal symptom for each upright swallow. Symptoms were graded on a 4-point likert score (0, none; 1, mild; 2, moderate; 3, severe). The individual liquid, viscous or solid upright swallow with the maximal symptom score was selected for analysis in each patient. HRM metrics were compared between groups with and without symptoms during the upright liquid protocol and the provocative protocols separately.
resultsA total of 269 patients recorded symptoms during the upright liquid swallows and 72 patients had a swallow symptom score of 1 or greater. Of the 269 patients, 116 recorded symptoms during viscous or solid swallows. HRM metrics were similar between swallows with and without associated symptoms in the upright, viscous, and solid swallows. No correlation was noted between HRM metrics and symptom scores among swallow types.
conclusionsEsophageal symptoms are not related to abnormal motor function defined by HRM during liquid, viscous or solid bolus swallows in the upright position. Other factors beyond circular muscle contraction patterns should be explored as possible causes of symptom generation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.