ArticleJournal of psychiatric research2014
Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments.
Article in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.BMC psychiatry · 2023Trial
- Article
- Dissociative experiences alter resting state functional connectivity after childhood abuse.Scientific reports · 2025Article
- Long-term effects of a double hit murine model for schizophrenia on parvalbumin expressing cells and plasticity-related molecules in the thalamic reticular nucleus and the habenula.Translational psychiatry · 2024Article
- The Necessity of Taking Culture and Context into Account When Studying the Relationship between Socioeconomic Status and Brain Development.Brain sciences · 2024Review
- Exposure to violence is associated with decreased neural connectivity in emotion regulation and cognitive control, but not working memory, networks after accounting for socioeconomic status: a preliminary study.Behavioral and brain functions : BBF · 2022Article
- Benefits from Repetitive Transcranial Magnetic Stimulation in Post-Stroke Rehabilitation.Journal of clinical medicine · 2022Review
- Grey matter covariation and the role of emotion reappraisal in mental wellbeing and resilience after early life stress exposure.Translational psychiatry · 2022Article
- Cumulative Childhood Maltreatment and Executive Functioning in Adulthood.Journal of aggression, maltreatment & trauma · 2021Article
- Childhood abuse history and attention bias in adults.Psychophysiology · 2020Article
- Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.Schizophrenia research · 2019Article
- Regional Prefrontal Resting-State Functional Connectivity in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Mechanism of Repetitive Transcranial Magnetic Stimulation for Depression.Shanghai archives of psychiatry · 2018Review
- Neural correlates of childhood trauma with executive function in young healthy adults.Oncotarget · 2017Article
- Interpersonal early-life trauma alters amygdala connectivity and sustained attention performance.Brain and behavior · 2017Article
- Altered neural connectivity in adult female rats exposed to early life social stress.Behavioural brain research · 2017Article
- Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity.Journal of psychiatric research · 2016Article
- Early life stress affects limited regional brain activity in depression.Scientific reports · 2016Article
- Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task.Brain imaging and behavior · 2016Article
- Maternal and pediatric health and disease: integrating biopsychosocial models and epigenetics.Pediatric research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Exposure to early life stress (ELS) is strongly associated with poor treatment outcomes, particularly for trauma-associated disorders such as depression. Little research to date, however, has examined the potential effects of ELS on outcomes with newer treatments, such as repetitive transcranial magnetic stimulation (rTMS). This study evaluated whether ELS exposure impacts resting state functional connectivity associated with brain regions targeted by rTMS. Twenty-seven medication-free adults without psychiatric or medical illness (14 with a history of at least moderate ELS) were scanned using a 3T magnetic resonance imaging (MRI) scanner during two 4-min rest periods. The primary targets of rTMS, the left and right dorsolateral prefrontal cortex (DLPFC), were utilized as seed regions in connectivity analyses. Relative to controls, when seeding the left DLPFC, ELS subjects demonstrated significantly increased local connectivity with the left middle frontal gyrus and negative connectivity with the left precuneus. ELS status was also associated with negative connectivity from the right DLPFC to the left precuneus and left inferior parietal lobule. These findings demonstrate greater dissociation between the executive and default mode networks in individuals with a history of ELS, and these results may inform neuroimaging assessments in future rTMS studies of ELS-related conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.