ArticleMicrobes and infection2014
Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota.
Article in Microbes and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of Helicobacter pylori infection on gastric mucosal microbiota.World journal of pediatrics : WJP · 2026Review
- Co-Infection Dynamics ofInternational journal of molecular sciences · 2025Review
- Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma.Microbiology spectrum · 2023Article
- [Gastric Cancer and Gastric Microbiome].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023Review
- Comparison of genomic and transcriptional microbiome analysis in gastric cancer patients and healthy individuals.World journal of gastroenterology · 2023Article
- Alterations in bacterial community dynamics from noncancerous to Gastric cancer.Frontiers in microbiology · 2023Article
- A framework for testing the impact of co-infections on host gut microbiomes.Animal microbiome · 2022Review
- The impact ofFrontiers in medicine · 2022Review
- Review
- Public Health struggles to square hygiene with diversity: Research on the link between microbiomes and immune function puts the "hygiene hypothesis" to rest.EMBO reports · 2020Article
- The role of gastric microbiota in gastric cancer.Gut microbes · 2020Review
- Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection.Cancer epidemiology · 2020Article
- The gut microbiota response to helminth infection depends on host sex and genotype.The ISME journal · 2020Article
- Changes in the severity of gastric mucosal inflammation associated with Helicobacter pylori in humans coinfected with intestinal helminths.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Dual infective burden of Helicobacter pylori and intestinal parasites: Good or bad news for the host?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Review
- Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages.Scientific reports · 2018Article
- Characterization of Gastric Microbiota in Twins.Current microbiology · 2017Article
- Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.Disease models & mechanisms · 2017Review
- Transgenic and gene knockout mice in gastric cancer research.Oncotarget · 2017Review
- Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Higher prevalence of helminth infections in Helicobacter pylori infected children was suggested to potentially lower the life-time risk for gastric adenocarcinoma. In rodent models, helminth co-infection does not reduce Helicobacter-induced inflammation but delays progression of pre-malignant gastric lesions. Because gastric cancer in INS-GAS mice is promoted by intestinal microflora, the impact of Heligmosomoides polygyrus co-infection on H. pylori-associated gastric lesions and microflora were evaluated. Male INS-GAS mice co-infected with H. pylori and H. polygyrus for 5 months were assessed for gastrointestinal lesions, inflammation-related mRNA expression, FoxP3(+) cells, epithelial proliferation, and gastric colonization with H. pylori and Altered Schaedler Flora. Despite similar gastric inflammation and high levels of proinflammatory mRNA, helminth co-infection increased FoxP3(+) cells in the corpus and reduced H. pylori-associated gastric atrophy (p < 0.04), dysplasia (p < 0.02) and prevented H. pylori-induced changes in the gastric flora (p < 0.05). This is the first evidence of helminth infection reducing H. pylori-induced gastric lesions while inhibiting changes in gastric flora, consistent with prior observations that gastric colonization with enteric microbiota accelerated gastric lesions in INS-GAS mice. Identifying how helminths reduce gastric premalignant lesions and impact bacterial colonization of the H. pylori infected stomach could lead to new treatment strategies to inhibit progression from chronic gastritis to cancer in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.