Evidence map›Paper›PMID 24513442›Full record

Trial reportBMJ (Clinical research ed.)2014

Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial.

Jodie M Dodd, Deborah Turnbull, Andrew J McPhee, Andrea R Deussen, Rosalie M Grivell, Lisa N Yelland, Caroline A Crowther, Gary Wittert, Julie A Owens, Jeffrey S Robinson and 1 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03146156 (Lifestyle Intervention in Preparation for Pregnancy), which is not on this map. Cited by 216 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 25 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03146156 nacompletednot on this mapstarted 2017, after this paper: background citation

Lifestyle Intervention in Preparation for Pregnancy (LIPP)

TypeinterventionalSponsorTufts Medical CenterRan2017 to 2025Enrolled99ConditionsObesity, Lifestyle-related Condition, Macrosomia, FetalArmsLifestyle Intervention
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 25 syntheses or guidelines pooled it.

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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jodie M DoddRobinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, 72 King William Road, North Adelaide, South Australia, Australia 5006.
Deborah Turnbull
Andrew J McPhee
Andrea R Deussen
Rosalie M Grivell
Lisa N Yelland
Caroline A Crowther
Gary Wittert
Julie A Owens
Jeffrey S Robinson
LIMIT Randomised Trial Group

Funding

Limiting Weight Gain in Overweight Pregnant Women: Effects on Mother and ChildR01HL094235 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2008 to 2011
$1.3M
NHLBI NIH HHS R01 HL094235
6 · The paper itself

Abstract

objectiveTo determine the effect of antenatal dietary and lifestyle interventions on health outcomes in overweight and obese pregnant women.

designMulticentre randomised trial. We utilised a central telephone randomisation server, with computer generated schedule, balanced variable blocks, and stratification for parity, body mass index (BMI) category, and hospital.

settingThree public maternity hospitals across South Australia.

participants2212 women with a singleton pregnancy, between 10+0 and 20+0 weeks' gestation, and BMI ≥ 25.

interventions1108 women were randomised to a comprehensive dietary and lifestyle intervention delivered by research staff; 1104 were randomised to standard care and received pregnancy care according to local guidelines, which did not include such information.

main outcome measuresIncidence of infants born large for gestational age (birth weight ≥ 90th centile for gestation and sex). Prespecified secondary outcomes included birth weight >4000 g, hypertension, pre-eclampsia, and gestational diabetes. Analyses used intention to treat principles.

results2152 women and 2142 liveborn infants were included in the analyses. The risk of the infant being large for gestational age was not significantly different in the two groups (lifestyle advice 203/1075 (19%) v standard care 224/1067 (21%); adjusted relative risk 0.90, 95% confidence interval 0.77 to 1.07; P=0.24). Infants born to women after lifestyle advice were significantly less likely to have birth weight above 4000 g (lifestyle advice 164/1075 (15%) v standard care 201/1067 (19%); 0.82, 0.68 to 0.99; number needed to treat (NNT) 28, 15 to 263; P=0.04). There were no differences in maternal pregnancy and birth outcomes between the two treatment groups.

conclusionsFor women who were overweight or obese, the antenatal lifestyle advice used in this study did not reduce the risk delivering a baby weighing above the 90th centile for gestational age and sex or improve maternal pregnancy and birth outcomes.

trial registrationAustralian and New Zealand Clinical Trials Registry (ACTRN12607000161426).

Indexed as

Health PromotionAdultBirth WeightDiabetes, GestationalFemaleFetal MacrosomiaGestational AgeHumansHypertensionInfant, NewbornMaleObesityOverweightPre-EclampsiaPregnancyPregnancy Complications

Identifiers

PMID24513442
PMCPMC3919179

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.